ELEVATED PLASMA PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE ACTIVITY AND ITS RELATIONSHIP TO THE PRESENCE OF CORONARY ARTERY DISEASE

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SAMSAMSHARIAT SAEDZIAALDIN; BASATI GHOLAM; MOVAHEDIAN AHMAD; POURFARZAM MORTEZA; SARRAFZADEGAN NIZAL

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2011 | Volume:16 | Issue:5 Page(s): 674-679

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Title

ELEVATED PLASMA PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE ACTIVITY AND ITS RELATIONSHIP TO THE PRESENCE OF CORONARY ARTERY DISEASE

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Keywords

PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE

STABLE CORONARY ARTERY DISEASE

UNSTABLE CORONARY ARTERY DISEASE

Abstract

BACKGROUND: PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE (PAF-AH) is a circulating enzyme that has an important role in the development of coronary artery disease (CAD). The correlations between PAF-AH and CAD are controversial.Furthermore, the differences of the enzyme levels between patients with stable and unstable CAD are not fully determined.The purpose of this study was to evaluate plasma PAF-AH levels and its association with the presence of CAD and some clinical risk factors in the patients.METHODS: This case-control study included 50 control subjects without CAD, 50 stable CAD patients and 50 unstable CAD patients with angiographically documented CAD. Plasma PAF-AH activity was determined by a commercial kit. The inflammatory markers, high sensitivity C-reactive protein (hsCRP) and oxidized low density lipoprotein (ox-LDL), and lipid profile were also measured. Comparisons of biochemical risk factors among all groups were performed by one way ANOVA. The association of PAF-AH activity with the presence of CAD was analyzed by multiple logistic regression.RESULTS: Plasma PAF-AH activity levels were higher in unstable CAD patients (0.040±0.012 μmol/min/ml) than in stable CAD patients (0.032±0.010μmol/min/ml) and control subjects (0.026±0.009 μmol/min/ml) (p<0.01). Plasma PAF-AH activity was also independently associated with the presence of CAD (p<0.01).CONCLUSIONS: Plasma PAF-AH activity levels were highly increased in unstable and stable CAD patients as compared to control subjects and may be a useful biomarker for CAD prediction.

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APA: Copy

SAMSAMSHARIAT, SAEDZIAALDIN, BASATI, GHOLAM, MOVAHEDIAN, AHMAD, POURFARZAM, MORTEZA, & SARRAFZADEGAN, NIZAL. (2011). ELEVATED PLASMA PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE ACTIVITY AND ITS RELATIONSHIP TO THE PRESENCE OF CORONARY ARTERY DISEASE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 16(5), 674-679. SID. https://sid.ir/paper/572763/en

Vancouver: Copy

SAMSAMSHARIAT SAEDZIAALDIN, BASATI GHOLAM, MOVAHEDIAN AHMAD, POURFARZAM MORTEZA, SARRAFZADEGAN NIZAL. ELEVATED PLASMA PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE ACTIVITY AND ITS RELATIONSHIP TO THE PRESENCE OF CORONARY ARTERY DISEASE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2011;16(5):674-679. Available from: https://sid.ir/paper/572763/en

IEEE: Copy

SAEDZIAALDIN SAMSAMSHARIAT, GHOLAM BASATI, AHMAD MOVAHEDIAN, MORTEZA POURFARZAM, and NIZAL SARRAFZADEGAN, “ELEVATED PLASMA PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE ACTIVITY AND ITS RELATIONSHIP TO THE PRESENCE OF CORONARY ARTERY DISEASE,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 16, no. 5, pp. 674–679, 2011, [Online]. Available: https://sid.ir/paper/572763/en

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