مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

INDOLEAMINE 2,3-DIOXYGENASE (IDO) IS EXPRESSED AT FETO-PLACENTAL UNIT THROUGHOUT MOUSE GESTATION: AN IMMUNOHISTOCHEMICAL STUDY

Pages

  177-183

Abstract

 Introduction: The cells expressing INDOLEAMINE 2, 3-DIOXYGENASE (IDO) in fetomaternal interface mediate tryptophan catabolism, hence protect allogeneic fetus from lethal rejection by maternal immune responses. In this study, we report immunolocalization of IDO+ cells in murine reproductive tract and PLACENTA throughout mouse PREGNANCY by IMMUNOHISTOCHEMISTRY.Materials and Methods: Syngeneic pregnant mice were examined for vaginal plug to discover about their state of PREGNANCY. A total of three pregnant mice were examined at each stage.The examination was further confirmed by the detection of sperm in vaginal smear. On the gestational days of 2nd, 12th and 18th, the uterus and OVIDUCT were removed and expression of IDO was investigated in the ENDOMETRIUM, PLACENTA and OVIDUCT by IMMUNOHISTOCHEMISTRY.Results: Our results showed that IDO is expressed consistently in feto-maternal interface throughout PREGNANCY. In ENDOMETRIUM, expression of IDO was predominantly confined to luminal and glandular epithelial cells. Cells at junctional and labyrinth zones of PLACENTA showed strong IDO immunoreactivity as well.Conclusion: Expression of IDO at the protein level in reproductive tract of pregnant mice during entire periods of gestation points to its potential protective role in maintenance of PREGNANCY. In our knowledge this is the first report of expression of IDO in feto-maternal phase during murine PREGNANCY.

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    Cite

    APA: Copy

    HEMATI, SH., JEDI TEHRANI, MAHMOUD, TORKABADI, E., GHASEMI, J., KAZEMI SEFAT, G.E., DANESH, P., BARZEGAR YARMOHAMMADI, L., AKHOUNDI, MOHAMMAD MAHDI, & ZARNANI, A.H.. (2009). INDOLEAMINE 2,3-DIOXYGENASE (IDO) IS EXPRESSED AT FETO-PLACENTAL UNIT THROUGHOUT MOUSE GESTATION: AN IMMUNOHISTOCHEMICAL STUDY. JOURNAL OF REPRODUCTION AND INFERTILITY, 10(3 (40)), 177-183. SID. https://sid.ir/paper/573074/en

    Vancouver: Copy

    HEMATI SH., JEDI TEHRANI MAHMOUD, TORKABADI E., GHASEMI J., KAZEMI SEFAT G.E., DANESH P., BARZEGAR YARMOHAMMADI L., AKHOUNDI MOHAMMAD MAHDI, ZARNANI A.H.. INDOLEAMINE 2,3-DIOXYGENASE (IDO) IS EXPRESSED AT FETO-PLACENTAL UNIT THROUGHOUT MOUSE GESTATION: AN IMMUNOHISTOCHEMICAL STUDY. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2009;10(3 (40)):177-183. Available from: https://sid.ir/paper/573074/en

    IEEE: Copy

    SH. HEMATI, MAHMOUD JEDI TEHRANI, E. TORKABADI, J. GHASEMI, G.E. KAZEMI SEFAT, P. DANESH, L. BARZEGAR YARMOHAMMADI, MOHAMMAD MAHDI AKHOUNDI, and A.H. ZARNANI, “INDOLEAMINE 2,3-DIOXYGENASE (IDO) IS EXPRESSED AT FETO-PLACENTAL UNIT THROUGHOUT MOUSE GESTATION: AN IMMUNOHISTOCHEMICAL STUDY,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 10, no. 3 (40), pp. 177–183, 2009, [Online]. Available: https://sid.ir/paper/573074/en

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