COMBINATION OF THROMBOPHILIC GENE POLYMORPHISMS AS A CAUSE OF INCREASED THE RISK OF RECURRENT PREGNANCY LOSS

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TORABI RAHELEH; ZAREI SAEED; ZERAATI HOJJAT; ZARNANI AMIR HASSAN; AKHONDI MOHAMMAD MEHDI; HADAVI REZA; SAVADI SHIRAZ ELHAM; JEDDI TEHRANI MAHMOOD

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Journal: Journal of Reproduction & Infertility Year:2012 | Volume:13 | Issue:2 (51) Page(s): 89-94

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Title

COMBINATION OF THROMBOPHILIC GENE POLYMORPHISMS AS A CAUSE OF INCREASED THE RISK OF RECURRENT PREGNANCY LOSS

Author(s)

Keywords

PCR-RFLP

RECURRENT PREGNANCY LOSS

THROMBOPHILIC GENE

Abstract

Background: RECURRENT PREGNANCY LOSS is (RPL) a heterogeneous condition. While the role of acquired thrombophilia has been accepted as an etiology for RPL, the contribution of specific inherited THROMBOPHILIC GENE polymorphisms to the disorder has been remained controversial.Methods: One hundred women with a history of two or more consecutive abortions and 100 women with at least two live births and no miscarriages were included in the study and evaluated for the presence of 11 THROMBOPHILIC GENE polymorphisms (Factor V LEIDEN, Factor V 4070 A/G, Factor V 5279 A/G, Factor XIII 103 G/T, Factor XIII 614 A/T, Factor XIII 1694 C/T, PAI-1 -675 4G/5G, ITGB3 1565 T/C, b-Fibrinogen -455G/A, MTHFR 677 C/T, MTHFR 1298 A/C) using PCR-RFLP technique. The data were statistically analyzed using Mann-Whitney test and logistic regression model.Results: There was no relation between factor XIII 103G/T gene polymorphism with increased risk of RPL. However, the other 10 gene polymorphisms were found to be associated with increased/decreased risk of RPL. Multiple logistic regression model for analyzing the simultaneous effects of these polymorphisms on the risk of RPL showed that six of these 11 polymorphisms (Factor V 1691G/A, Factor V 5279A/G, Factor XIII 614A/T, b-Fibrinogen -455G/A, ITGB3 1565T/C, and MTHFR 1298A/ C) were associated with RPL.Conclusion: It is possible to calculate the risk of abortion in a patient with RPL by determining only six of the 10 polymorphisms that are individually associated with RPL.

Cites

ASSOCIATION OF G103T POLYMORPHISM OF COAGULATION FACTOR XIII WITH RECURRENT PREGNANCY LOSS IN NORTHWEST OF IRAN

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APA: Copy

TORABI, RAHELEH, ZAREI, SAEED, ZERAATI, HOJJAT, ZARNANI, AMIR HASSAN, AKHONDI, MOHAMMAD MEHDI, HADAVI, REZA, SAVADI SHIRAZ, ELHAM, & JEDDI TEHRANI, MAHMOOD. (2012). COMBINATION OF THROMBOPHILIC GENE POLYMORPHISMS AS A CAUSE OF INCREASED THE RISK OF RECURRENT PREGNANCY LOSS. JOURNAL OF REPRODUCTION AND INFERTILITY, 13(2 (51)), 89-94. SID. https://sid.ir/paper/573766/en

Vancouver: Copy

TORABI RAHELEH, ZAREI SAEED, ZERAATI HOJJAT, ZARNANI AMIR HASSAN, AKHONDI MOHAMMAD MEHDI, HADAVI REZA, SAVADI SHIRAZ ELHAM, JEDDI TEHRANI MAHMOOD. COMBINATION OF THROMBOPHILIC GENE POLYMORPHISMS AS A CAUSE OF INCREASED THE RISK OF RECURRENT PREGNANCY LOSS. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2012;13(2 (51)):89-94. Available from: https://sid.ir/paper/573766/en

IEEE: Copy

RAHELEH TORABI, SAEED ZAREI, HOJJAT ZERAATI, AMIR HASSAN ZARNANI, MOHAMMAD MEHDI AKHONDI, REZA HADAVI, ELHAM SAVADI SHIRAZ, and MAHMOOD JEDDI TEHRANI, “COMBINATION OF THROMBOPHILIC GENE POLYMORPHISMS AS A CAUSE OF INCREASED THE RISK OF RECURRENT PREGNANCY LOSS,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 13, no. 2 (51), pp. 89–94, 2012, [Online]. Available: https://sid.ir/paper/573766/en

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