INTRANASAL MIDAZOLAM COMPARED WITH INTRAVENOUS DIAZEPAM IN PATIENTS SUFFERING FROM ACUTE SEIZURE: A RANDOMIZED CLINICAL TRIAL

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JAVADZADEH MOHSEN; SHEIBANI KOUROSH; HASHEMIEH MOZHGAN; SANEIFARD HEDYEH

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Journal: Iranian Journal of Pediatrics Year:2012 | Volume:22 | Issue:1 Page(s): 1-8

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Title

INTRANASAL MIDAZOLAM COMPARED WITH INTRAVENOUS DIAZEPAM IN PATIENTS SUFFERING FROM ACUTE SEIZURE: A RANDOMIZED CLINICAL TRIAL

Author(s)

JAVADZADEH MOHSEN | SHEIBANI KOUROSH | HASHEMIEH MOZHGAN | SANEIFARD HEDYEH | Issue Writer Certificate

Keywords

MIDAZOLAM

DIAZEPAM

SEIZURES

CLINICAL TRAIL

Abstract

Objective: Acute seizure attack is a stressful experience both for health care personnel and parents. These attacks might cause morbidity and mortality among patients, so reliable methods to control the seizure preferably at home should be developed. This study was performed to measure the time needed to control seizure attacks using intranasal MIDAZOLAM compared to the common treatment (intravenous DIAZEPAM) and to evaluate its probable side effects.Methods: This study was conducted as a not blind randomized clinical trial among 60 patients coming to Imam Ali Hospital, Zahedan, Iran. The patients were 2 months to 15 years old children coming to our emergency department suffering from an acute seizure episode. Intranasal MIDAZOLAM was administered 0.2 mg/kg equally dropped in both nostrils for case group and intravenous DIAZEPAM was administered 0.3mg/kg via IV line for control group. After both treatments the time needed to control the seizure was registered by the practitioner. Pulse rate and O2 saturation were recorded at patients’ entrance and in minutes 5 and 10 after drug administration.Findings: The time needed to control seizure using intranasal MIDAZOLAM (3.16±1.24) was statistically shorter than intravenous DIAZEPAM (6.42±2.59) if the time needed to establish IV line in patients treated by intravenous DIAZEPAM is taken into account (P<0.001). The readings for O2 saturation or heart rate did not indicate a statistically significant difference between two groups of patients either at entrance or 5 and 10 minutes after drug administration.Conclusion: Considering the shorter time needed to control acute seizure episodes compared to intravenous DIAZEPAM and its safety record, intranasal MIDAZOLAM seems to be a good candidate to replace DIAZEPAM, as the drug of choice, in controlling this condition.

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APA: Copy

JAVADZADEH, MOHSEN, SHEIBANI, KOUROSH, HASHEMIEH, MOZHGAN, & SANEIFARD, HEDYEH. (2012). INTRANASAL MIDAZOLAM COMPARED WITH INTRAVENOUS DIAZEPAM IN PATIENTS SUFFERING FROM ACUTE SEIZURE: A RANDOMIZED CLINICAL TRIAL. IRANIAN JOURNAL OF PEDIATRICS, 22(1), 1-8. SID. https://sid.ir/paper/574592/en

Vancouver: Copy

JAVADZADEH MOHSEN, SHEIBANI KOUROSH, HASHEMIEH MOZHGAN, SANEIFARD HEDYEH. INTRANASAL MIDAZOLAM COMPARED WITH INTRAVENOUS DIAZEPAM IN PATIENTS SUFFERING FROM ACUTE SEIZURE: A RANDOMIZED CLINICAL TRIAL. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2012;22(1):1-8. Available from: https://sid.ir/paper/574592/en

IEEE: Copy

MOHSEN JAVADZADEH, KOUROSH SHEIBANI, MOZHGAN HASHEMIEH, and HEDYEH SANEIFARD, “INTRANASAL MIDAZOLAM COMPARED WITH INTRAVENOUS DIAZEPAM IN PATIENTS SUFFERING FROM ACUTE SEIZURE: A RANDOMIZED CLINICAL TRIAL,” IRANIAN JOURNAL OF PEDIATRICS, vol. 22, no. 1, pp. 1–8, 2012, [Online]. Available: https://sid.ir/paper/574592/en

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