A COMPARISON BETWEEN THE EFFICACY OF INTRALESIONAL INJECTION OF 2% ZINC SULFATE SOLUTION WITH
GLUCANTIME IN THE TREATMENT OF ACUTE OLD WORLD CUTANEOUS LEISHMANIASIS: A RANDOMIZED, DOUBLEBLIND,
CONTROLLED CLINICAL TRIAL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FIROUZ A.R.; KHATAMI A.R.; KHAMESIPOUR A.; NASIRI KASHANI M.; NILFOROUSHZADEH MOHAMMAD ALI; BEHNIA F.; PAZOUKI TOROUDI H.R.; DOULATI Y.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Dermatology Year:2004 | Volume:7 | Issue:4 Page(s): 209-218

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,051

Download:

Cites:

Information Journal Paper

Title

A COMPARISON BETWEEN THE EFFICACY OF INTRALESIONAL INJECTION OF 2% ZINC SULFATE SOLUTION WITH GLUCANTIME IN THE TREATMENT OF ACUTE OLD WORLD CUTANEOUS LEISHMANIASIS: A RANDOMIZED, DOUBLEBLIND, CONTROLLED CLINICAL TRIAL

Author(s)

Keywords

CLINICAL TRIALQ3

LEISHMANIA MAJORQ3

CUTANEOUS LEISHMANIASISQ4

Abstract

Background: Several treatment modalities have been used for CUTANEOUS LEISHMANIASIS (CL) with various results. In vitro and in vivo studies have shown inhibitory effects of zinc sulfate (ZnS04) on Leishmania parasites. Objective: To compare the efficacy of intralesional injections of 2% ZnS04 solution with meglumine antimonate (Glucantime) in the treatment of acute Old World CL. Patients & Methods: Seventy-two patients with CL with a duration of less than 8 weeks were recruited in a randomized, double-blind, CLINICAL TRIAL in Isfahan province-an area endemic for LEISHMANIA MAJOR-after giving written informed consent. They were treated with 6 weekly intralesional injections of either 2% sterile ZnSO4 solutions or Glucantime prepared in identical vials. The primary outcome measure was complete re-epithelialization of CL lesions. Results: Among 36 patients with 53 lesions treated with ZnS04 and 36 patients with 53 lesions treated with Glucantime, 13patients with 19 lesions and 22 patients with 31 lesions completed the trial, respectively. Inadequacy of treatment was the main reason for drop-out in 12 (33.3%) and 2 (5.5%) patients in ZnS04 and Glucantime groups, respectively (P<0.05). Complete re-epithelialization was observed in 2 (10.5%) and 19(61.3%) lesions 1 week after the end of treatment in the ZnS04 and Glucantime groups, respectively (P<0.05). Conclusion: A six-week course of weekly intralesional injections of 2% ZnSO4 solution was less effective than Glucantime in the treatment of acute Old World CL.

Cites

No record.

References

ORAL ZINC SULFATE IN THE TREATMENT OF ACUTE CUTANEOUS LEISHMANIASIS

Cite

APA: Copy

FIROUZ, A.R., KHATAMI, A.R., KHAMESIPOUR, A., NASIRI KASHANI, M., NILFOROUSHZADEH, MOHAMMAD ALI, BEHNIA, F., PAZOUKI TOROUDI, H.R., & DOULATI, Y.. (2004). A COMPARISON BETWEEN THE EFFICACY OF INTRALESIONAL INJECTION OF 2% ZINC SULFATE SOLUTION WITH GLUCANTIME IN THE TREATMENT OF ACUTE OLD WORLD CUTANEOUS LEISHMANIASIS: A RANDOMIZED, DOUBLEBLIND, CONTROLLED CLINICAL TRIAL. IRANIAN JOURNAL OF DERMATOLOGY, 7(4), 209-218. SID. https://sid.ir/paper/57695/en

Vancouver: Copy

FIROUZ A.R., KHATAMI A.R., KHAMESIPOUR A., NASIRI KASHANI M., NILFOROUSHZADEH MOHAMMAD ALI, BEHNIA F., PAZOUKI TOROUDI H.R., DOULATI Y.. A COMPARISON BETWEEN THE EFFICACY OF INTRALESIONAL INJECTION OF 2% ZINC SULFATE SOLUTION WITH GLUCANTIME IN THE TREATMENT OF ACUTE OLD WORLD CUTANEOUS LEISHMANIASIS: A RANDOMIZED, DOUBLEBLIND, CONTROLLED CLINICAL TRIAL. IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2004;7(4):209-218. Available from: https://sid.ir/paper/57695/en

IEEE: Copy

A.R. FIROUZ, A.R. KHATAMI, A. KHAMESIPOUR, M. NASIRI KASHANI, MOHAMMAD ALI NILFOROUSHZADEH, F. BEHNIA, H.R. PAZOUKI TOROUDI, and Y. DOULATI, “A COMPARISON BETWEEN THE EFFICACY OF INTRALESIONAL INJECTION OF 2% ZINC SULFATE SOLUTION WITH GLUCANTIME IN THE TREATMENT OF ACUTE OLD WORLD CUTANEOUS LEISHMANIASIS: A RANDOMIZED, DOUBLEBLIND, CONTROLLED CLINICAL TRIAL,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 7, no. 4, pp. 209–218, 2004, [Online]. Available: https://sid.ir/paper/57695/en

Related Journal Papers