PROPHYLACTIC OPHTHALMIC BETHAMETAZONE FOR SULFUR MUSTARD-INDUCED OCULAR INJURY

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NADERI MOSTAFA; KAKA GH.R.; JADIDI KH.; KHODAMI VISHTEH H.R.; SHAMSPOUR N.; SADRAEI S.H.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2009 | Volume:14 | Issue:5 Page(s): 291-295

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Title

PROPHYLACTIC OPHTHALMIC BETHAMETAZONE FOR SULFUR MUSTARD-INDUCED OCULAR INJURY

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Keywords

BETAMETHASONE

SULFUR MUSTARD

OCULAR LESIONS

Abstract

BACKGROUND: The present study sought to evaluate the prophylactic effect of bethametazone on SULFUR MUSTARD (SM)- induced ocular morphometric damage in the rabbit eye.METHODS: Twenty five healthy New Zealand white rabbits were divided into 4 groups of normal (not exposed to SM or solution), solution (exposed to solution), SM (exposed to SM), and prophylactic bethametazone (received eye solution of bethametazone then exposed to SM solution; then treated for 2 weeks). On the day 14 after exposure, five-micron sections were stained with haematoxylin and eosin for light microscopy evaluation. The ocular morphometric characteristics in the study groups were compared to determine the prophylactic effects of the bethametazone.RESULTS: Bethamethazone could protect eyes from SM effect by means of decrease in changes in number of Keratocyte in 10000 mm2, thickness of cornea (mm), thickness of corneal epithelium (mm), number of meibomian gland's cells in 2500 mm2, thickness of palpebral conjuctival epithelium (mm), thickness of epithelial of palpebral skin (mm), number of epithelial layers of palpebral skin, and number of goblet cells in conjunctival sac in 1000 mm.CONCLUSIONS: Bethametazone may have a prophylactic effect on the early lesions of the eye of the rabbit due to SM exposure.

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APA: Copy

NADERI, MOSTAFA, KAKA, GH.R., JADIDI, KH., KHODAMI VISHTEH, H.R., SHAMSPOUR, N., & SADRAEI, S.H.. (2009). PROPHYLACTIC OPHTHALMIC BETHAMETAZONE FOR SULFUR MUSTARD-INDUCED OCULAR INJURY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 14(5), 291-295. SID. https://sid.ir/paper/577044/en

Vancouver: Copy

NADERI MOSTAFA, KAKA GH.R., JADIDI KH., KHODAMI VISHTEH H.R., SHAMSPOUR N., SADRAEI S.H.. PROPHYLACTIC OPHTHALMIC BETHAMETAZONE FOR SULFUR MUSTARD-INDUCED OCULAR INJURY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2009;14(5):291-295. Available from: https://sid.ir/paper/577044/en

IEEE: Copy

MOSTAFA NADERI, GH.R. KAKA, KH. JADIDI, H.R. KHODAMI VISHTEH, N. SHAMSPOUR, and S.H. SADRAEI, “PROPHYLACTIC OPHTHALMIC BETHAMETAZONE FOR SULFUR MUSTARD-INDUCED OCULAR INJURY,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 14, no. 5, pp. 291–295, 2009, [Online]. Available: https://sid.ir/paper/577044/en

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