COMBINATION OF STEM CELL MOBILIZED BY GRANULOCYTE-COLONY STIMULATING FACTOR AND HUMAN UMBILICAL CORD MATRIX STEM CELL: THERAPY OF TRAUMATIC BRAIN INJURY IN RATS

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BAKHTIARY MEHRDAD; MARZBAN MOHSEN; MEHDIZADEH MEHDI; JOGHATAEI MOHAMMAD TAGHI; KHOEI SAMIDEH; TONDAR MAHDI; PIRHAJATI MAHABADI VAHID; LARIBI BAHAREH; EBRAHIMI ASGHAR; HASHEMIAN SEYED JAFAR; MODIRY NAVID; MEHRABI SORAYA

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Journal: Iranian Journal of Basic Medical Sciences Year:2011 | Volume:14 | Issue:4 (51) Page(s): 327-339

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Title

COMBINATION OF STEM CELL MOBILIZED BY GRANULOCYTE-COLONY STIMULATING FACTOR AND HUMAN UMBILICAL CORD MATRIX STEM CELL: THERAPY OF TRAUMATIC BRAIN INJURY IN RATS

Author(s)

Keywords

COMBINE THERAPY

G-CSF

STEM CELL

TBI

WHARTON’S JELLY

Abstract

Objective (s): Clinical studies of treating traumatic brain injury (TBI) with autologous adult STEM CELLs led us to examine the impression of a combination therapy. This was performed by intravenous injection of human umbilical cord matrix STEM CELL (hUCMSC-Wharton’s jelly STEM CELL) with bone marrow cell mobilized by granulocytecolony stimulating factor (G-CSF) in rats injured with cortical compact device.Materials and Methods: Adult male Wistar rats (n=50) were injured with controlled cortical impact device and divided into five groups. All injections were performed 1 day after injury into the tail veins of rats. Neurological functional evaluation of animals was performed before and after injury using modified neurological severity scores (mNSS). Animals were sacrificed 42 days after TBI and brain sections were stained by Brdu immunohistochemistry.Results: Statistically significant improvement in functional outcome was observed in treatment groups when compared with control (P<0.01). mNSS showed no significant differences among the hUCMSC and G-CSF treated groups at any time point (end of trial). Rats with hUCMSC+G-CSF treatment had a significant improvement on mNSS at 5 and 6 week compared to other treatment group (P<0.01).Conclusion: Histological analysis in G-CSF+hUCMSC treated traumatic rats exhibited significant increase in numbers of Brdu immunoreactive cells in their traumatic core compared with other labeled group.

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APA: Copy

BAKHTIARY, MEHRDAD, MARZBAN, MOHSEN, MEHDIZADEH, MEHDI, JOGHATAEI, MOHAMMAD TAGHI, KHOEI, SAMIDEH, TONDAR, MAHDI, PIRHAJATI MAHABADI, VAHID, LARIBI, BAHAREH, EBRAHIMI, ASGHAR, HASHEMIAN, SEYED JAFAR, MODIRY, NAVID, & MEHRABI, SORAYA. (2011). COMBINATION OF STEM CELL MOBILIZED BY GRANULOCYTE-COLONY STIMULATING FACTOR AND HUMAN UMBILICAL CORD MATRIX STEM CELL: THERAPY OF TRAUMATIC BRAIN INJURY IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 14(4 (51)), 327-339. SID. https://sid.ir/paper/577113/en

Vancouver: Copy

BAKHTIARY MEHRDAD, MARZBAN MOHSEN, MEHDIZADEH MEHDI, JOGHATAEI MOHAMMAD TAGHI, KHOEI SAMIDEH, TONDAR MAHDI, PIRHAJATI MAHABADI VAHID, LARIBI BAHAREH, EBRAHIMI ASGHAR, HASHEMIAN SEYED JAFAR, MODIRY NAVID, MEHRABI SORAYA. COMBINATION OF STEM CELL MOBILIZED BY GRANULOCYTE-COLONY STIMULATING FACTOR AND HUMAN UMBILICAL CORD MATRIX STEM CELL: THERAPY OF TRAUMATIC BRAIN INJURY IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2011;14(4 (51)):327-339. Available from: https://sid.ir/paper/577113/en

IEEE: Copy

MEHRDAD BAKHTIARY, MOHSEN MARZBAN, MEHDI MEHDIZADEH, MOHAMMAD TAGHI JOGHATAEI, SAMIDEH KHOEI, MAHDI TONDAR, VAHID PIRHAJATI MAHABADI, BAHAREH LARIBI, ASGHAR EBRAHIMI, SEYED JAFAR HASHEMIAN, NAVID MODIRY, and SORAYA MEHRABI, “COMBINATION OF STEM CELL MOBILIZED BY GRANULOCYTE-COLONY STIMULATING FACTOR AND HUMAN UMBILICAL CORD MATRIX STEM CELL: THERAPY OF TRAUMATIC BRAIN INJURY IN RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 14, no. 4 (51), pp. 327–339, 2011, [Online]. Available: https://sid.ir/paper/577113/en

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