مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

295
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

243
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

THE EFFECTS OF ACHILLEA WILHELMSII EXTRACT ON RAT’S GASTRIC MOTILITY AT BASAL AND VAGAL STIMULATED CONDITIONS

Pages

  151-157

Abstract

 Objective(s) Achillea genius is widely used in traditional medicine for gastrointestinal disorders. The aim of this study was to investigate the effects of aqueous-ethanol extract of ACHILLEA WILHELMSII on rat’s gastric motility in basal and vagal stimulated conditions. Materials and Methods Twenty four Wistar rats were randomly divided into two groups: control and test. The extract was prepared by maceration which was used to prepare three 0.5 ml samples of three doses (0.5, 1 and 2 mg/kg) in the test group. The same volume of saline was used in the control group. Gastric motility was measured by inserting a small balloon in the stomach which was connected to a pressure transducer. The data were recorded for 25 min duration after each dose and these data were analyzed for 3 intermittent five min intervals (t1=0-5, t2= 10-15 and t3=20-25 min). ResultsThe extract at basal condition decreased intragastric pressure (IGP) by 1 mg/kg dose in the t3 and 2 mg/kg in the t2 and t3 intervals. The extract at vagal stimulated condition decreased IGP by 1 and 2 mg/kg doses in the t2 and t3 intervals. The extract reduced contraction amplitude at basal condition by 2 mg/kg dose in the t2 and t3 intervals. At vagal stimulated condition contraction amplitude was reduced by 1 mg/kg dose in the t2 and t3 by 2 mg/kg in all three intervals. The extract showed no effect on frequency of gastric contraction in either basal or vagal stimulated conditions. Conclusion The extract showed an inhibitory effect on gastric motility in both basal and vagal stimulated condition. This inhibitory effect may be exerted by an antagonistic effect on acetylcholine dependent calcium influx or release of calcium from intracellular storage in gastric smooth muscle.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    NIAZMAND, SAEED, & KHOSHNOOD, ESMAT. (2011). THE EFFECTS OF ACHILLEA WILHELMSII EXTRACT ON RAT’S GASTRIC MOTILITY AT BASAL AND VAGAL STIMULATED CONDITIONS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 14(2 (49)), 151-157. SID. https://sid.ir/paper/577531/en

    Vancouver: Copy

    NIAZMAND SAEED, KHOSHNOOD ESMAT. THE EFFECTS OF ACHILLEA WILHELMSII EXTRACT ON RAT’S GASTRIC MOTILITY AT BASAL AND VAGAL STIMULATED CONDITIONS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2011;14(2 (49)):151-157. Available from: https://sid.ir/paper/577531/en

    IEEE: Copy

    SAEED NIAZMAND, and ESMAT KHOSHNOOD, “THE EFFECTS OF ACHILLEA WILHELMSII EXTRACT ON RAT’S GASTRIC MOTILITY AT BASAL AND VAGAL STIMULATED CONDITIONS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 14, no. 2 (49), pp. 151–157, 2011, [Online]. Available: https://sid.ir/paper/577531/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button