RELAXATORY EFFECT OF GAMMA-AMINOBUTYRIC ACID (GABA) IS MEDIATED BY SAME PATHWAY IN DIABETIC AND NORMAL RAT MESENTERIC BED VESSEL

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FARSI LEILA; KESHAVARZ MANSOOR; SOLTANI NEPTON

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2011 | Volume:14 | Issue:1 (48) Page(s): 94-98

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Title

RELAXATORY EFFECT OF GAMMA-AMINOBUTYRIC ACID (GABA) IS MEDIATED BY SAME PATHWAY IN DIABETIC AND NORMAL RAT MESENTERIC BED VESSEL

Author(s)

FARSI LEILA | KESHAVARZ MANSOOR | SOLTANI NEPTON | Issue Writer Certificate

Keywords

DIABETES

ENDOTHELIUM

GABA

MESENTERIC ARTERIES

RAT

Abstract

Objective(s) DIABETES related dysfunction of resistance vessels is associated with vascular occlusive diseases.Vasorelaxant agents may have a role in control of diabetic cardiovascular complications. Gamma aminobutyric acid (GABA) has demonstrated to cause vasorelaxation. The present study was designed to determine i) the vasorelaxatory effect of GABA on diabetic vessels and ii) the role of ENDOTHELIUM in GABAinduced vasorelaxation.Materials and Methods After DIABETES induction, . MESENTERIC ARTERIES of animals were perfused. Vascular beds were constricted with phenylephrine. GABA (1 to 50 mM) was added into the medium and perfusion pressure was then recorded.Results In all groups of animals, relaxant response to GABA in mesenteric bed appeared. Although DIABETES induction did not change mesenteric bed response to GABA, denuded vessels showed a reduced response to GABA both in control and diabetic animals.Conclusion GABA can induce ENDOTHELIUM dependent vasorelaxation in mesenteric vessels in normal and diabetic RATs.

Cites

ROLE OF GABAB RECEPTOR AND L-ARG IN GABA-INDUCED VASORELAXATION IN NON-DIABETIC AND STREPTOZOTOCIN- INDUCED DIABETIC RAT VESSELS

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APA: Copy

FARSI, LEILA, KESHAVARZ, MANSOOR, & SOLTANI, NEPTON. (2011). RELAXATORY EFFECT OF GAMMA-AMINOBUTYRIC ACID (GABA) IS MEDIATED BY SAME PATHWAY IN DIABETIC AND NORMAL RAT MESENTERIC BED VESSEL. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 14(1 (48)), 94-98. SID. https://sid.ir/paper/577539/en

Vancouver: Copy

FARSI LEILA, KESHAVARZ MANSOOR, SOLTANI NEPTON. RELAXATORY EFFECT OF GAMMA-AMINOBUTYRIC ACID (GABA) IS MEDIATED BY SAME PATHWAY IN DIABETIC AND NORMAL RAT MESENTERIC BED VESSEL. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2011;14(1 (48)):94-98. Available from: https://sid.ir/paper/577539/en

IEEE: Copy

LEILA FARSI, MANSOOR KESHAVARZ, and NEPTON SOLTANI, “RELAXATORY EFFECT OF GAMMA-AMINOBUTYRIC ACID (GABA) IS MEDIATED BY SAME PATHWAY IN DIABETIC AND NORMAL RAT MESENTERIC BED VESSEL,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 14, no. 1 (48), pp. 94–98, 2011, [Online]. Available: https://sid.ir/paper/577539/en

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