EFFICACY OF TOPICAL IMMUNOTHERAPY OF EXTENSIVE AND/OR CHRONIC ALOPECIA AREATA WITH DIPHENCYPRONE

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EMAD M.; AGHAEI SH.; JAFARI P.

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Journal: Iranian Journal of Dermatology Year:2005 | Volume:8 | Issue:3 Page(s): 211-217

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Information Journal Paper

Title

EFFICACY OF TOPICAL IMMUNOTHERAPY OF EXTENSIVE AND/OR CHRONIC ALOPECIA AREATA WITH DIPHENCYPRONE

Author(s)

EMAD M. | AGHAEI SH. | JAFARI P. | Issue Writer Certificate

Keywords

ALOPECIA AREATAQ4

DIPHENCYPRONEQ4

TOPICAL IMMUNOTHERAPYQ4

SHIRAZQ4

Abstract

Background: Highly variable results of topical immunotherapy with DIPHENCYPRONE (DPC) in the treatment of ALOPECIA AREATA have been reported so far. Objective: The purpose of this study was to evaluate the efficacy and tolerability of DPC in the treatment of severe and chronic ALOPECIA AREATA. Patients and Methods: Twenty-eight patients (16 female and 12 male, 10-35 years old, mean age 25 years) with chronic and/or extensive ALOPECIA AREATA were enrolled in an open-label clinical trial. After sensitization with 2% DPC, progressively higher concentrations beginning at 0.001% were applied weekly for 6 months to one side of the scalp. The maximum concentration of DPC was 2%. Results: Twenty-seven of 28 patients completed therapy. The overall response rate was 81.5% (22 cases). Complete response (90% -100% terminal hair re-growth) was obtained in 22.2% (6 cases) and partial response (10%-90% terminal hair re-growth) in 59.3% (16 cases) , and 18.5% (5 cases) showed no regrowth. In all patients an eczematous reaction consisting of erythema, itching, and scaling at the site of application was observed. Other observed side effects included occipital lymphadenopathy in 40.7% (11 cases), severe eczema /blister formation in 40.7% (11 cases) , hyperpigmentation in 18.5% (5 cases). Notably, partial recurrence was observed in 66.7% (18 cases) of these patients after 6 to 12 months of follow up. Conclusion: Topical DPC treatment for ALOPECIA AREATA is an effective therapy with a relatively high relapse rate.

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APA: Copy

EMAD, M., AGHAEI, SH., & JAFARI, P.. (2005). EFFICACY OF TOPICAL IMMUNOTHERAPY OF EXTENSIVE AND/OR CHRONIC ALOPECIA AREATA WITH DIPHENCYPRONE. IRANIAN JOURNAL OF DERMATOLOGY, 8(3), 211-217. SID. https://sid.ir/paper/57811/en

Vancouver: Copy

EMAD M., AGHAEI SH., JAFARI P.. EFFICACY OF TOPICAL IMMUNOTHERAPY OF EXTENSIVE AND/OR CHRONIC ALOPECIA AREATA WITH DIPHENCYPRONE. IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2005;8(3):211-217. Available from: https://sid.ir/paper/57811/en

IEEE: Copy

M. EMAD, SH. AGHAEI, and P. JAFARI, “EFFICACY OF TOPICAL IMMUNOTHERAPY OF EXTENSIVE AND/OR CHRONIC ALOPECIA AREATA WITH DIPHENCYPRONE,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 8, no. 3, pp. 211–217, 2005, [Online]. Available: https://sid.ir/paper/57811/en

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