CAN REPEATED EXPOSURE TO MORPHINE CHANGE THE SPINAL ANALGESIC EFFECTS OF LIDOCAINE IN RATS? (SHORT COMMUNICATION)

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DABBAGH ALI; FARKHONDEHKISH MOGHADAM SHERVIN; RAJAEI SAMIRA; MANSOURI ZAHRA; SHARDI MANAHEJI HOMA

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2011 | Volume:16 | Issue:10 Page(s): 1361-1365

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Title

CAN REPEATED EXPOSURE TO MORPHINE CHANGE THE SPINAL ANALGESIC EFFECTS OF LIDOCAINE IN RATS? (SHORT COMMUNICATION)

Author(s)

Keywords

MORPHINE

INTRATHECAL

LIDOCAINE

LOCAL ANESTHETIC

Abstract

BACKGROUND: Chronic opium exposure leads to altered response to opioid compounds. The aim of this study was to assess the behavioral effects of opium tolerance on the analgesic effects of INTRATHECAL LIDOCAINE in rats.METHODS: Twenty-four adult male Sprague Dawley rats with INTRATHECAL (IT) catheters were divided into 3 groups of 8. The first group was MORPHINE tolerant and received IT LIDOCAINE (ML). Rats in the second group were not MORPHINE tolerant and received IT LIDOCAINE (L), while the third group consisted of not MORPHINE tolerant rats that received IT placebo. Tail flick test was done and maximal possible antinociceptive effects (MPAE) were compared using analysis of variance (ANOVA).RESULTS: While percent of MPAE significantly increased in the L group, it had a significant reduction in the ML group (P<0.001).CONCLUSIONS: After INTRATHECAL LIDOCAINE administration, a hyperalgesic response was seen in MORPHINE tolerant rats and an analgesic response was seen in the LIDOCAINE group.

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APA: Copy

DABBAGH, ALI, FARKHONDEHKISH MOGHADAM, SHERVIN, RAJAEI, SAMIRA, MANSOURI, ZAHRA, & SHARDI MANAHEJI, HOMA. (2011). CAN REPEATED EXPOSURE TO MORPHINE CHANGE THE SPINAL ANALGESIC EFFECTS OF LIDOCAINE IN RATS? (SHORT COMMUNICATION). JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 16(10), 1361-1365. SID. https://sid.ir/paper/578363/en

Vancouver: Copy

DABBAGH ALI, FARKHONDEHKISH MOGHADAM SHERVIN, RAJAEI SAMIRA, MANSOURI ZAHRA, SHARDI MANAHEJI HOMA. CAN REPEATED EXPOSURE TO MORPHINE CHANGE THE SPINAL ANALGESIC EFFECTS OF LIDOCAINE IN RATS? (SHORT COMMUNICATION). JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2011;16(10):1361-1365. Available from: https://sid.ir/paper/578363/en

IEEE: Copy

ALI DABBAGH, SHERVIN FARKHONDEHKISH MOGHADAM, SAMIRA RAJAEI, ZAHRA MANSOURI, and HOMA SHARDI MANAHEJI, “CAN REPEATED EXPOSURE TO MORPHINE CHANGE THE SPINAL ANALGESIC EFFECTS OF LIDOCAINE IN RATS? (SHORT COMMUNICATION),” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 16, no. 10, pp. 1361–1365, 2011, [Online]. Available: https://sid.ir/paper/578363/en

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