USE OF 18 AND 36 KDA ANTIGENS OF MYCOBACTERIUM LEPRAE FOR DETECTION OF THIS MICRO-ORGANISM IN
IRANIAN LEPROSY PATIENTS BY PCR

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SADEGHI V.; MAGHSOUDI N.; DOULATI Y.; DELDAR A.A.; HEYDARI SERAJ M.

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Journal Paper

Paper Information

Journal: Iranian Journal of Dermatology Year:2005 | Volume:8 | Issue: 5 (33) Page(s): 388-393

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Title

USE OF 18 AND 36 KDA ANTIGENS OF MYCOBACTERIUM LEPRAE FOR DETECTION OF THIS MICRO-ORGANISM IN IRANIAN LEPROSY PATIENTS BY PCR

Author(s)

Keywords

LEPROSYQ3

MOLECULAR DIAGNOSISQ3

MYCOBACTERIUM LEPREAQ2

PCRQ4

Abstract

Background and Objective: Mycobacterium leprae is an intracellular micro-organism that is the causative agent of LEPROSY. This micro-organism has a long division time and does not grow in vitro. For there reasons it is difficult to evaluate the effects of drugs on it. Amongst techniques used for detection of micro-organisms polymerase chain reaction (PCR) is promising. This study was conducted to diagnose lyprosy using two antigens by PCR. Materials and Methods: In this study by selecting specific M. leprae 36 kDa and 18kDa antigens, a set of primers were designed for each gene and biopsies from 15patients were screened for presence of M. leprae by PCR. Results: Specific segments of M. leprae antigens were replicated in 5 patients with these primers. Conclusion: PCR is a relevant and promising method for M.leprae detection in biopsies of LEPROSY patients and it can be considered as a method of choice for early LEPROSY detection, especially in high risk groups.

Cites

COMPARISON OF SLIT SKIN SMEAR AND PCR IN DIAGNOSIS OF MYCOBACTERIUM LEPRAE IN PATIENTS BABABAGHI HOSPITAL, TABRIZ

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APA: Copy

SADEGHI, V., MAGHSOUDI, N., DOULATI, Y., DELDAR, A.A., & HEYDARI SERAJ, M.. (2005). USE OF 18 AND 36 KDA ANTIGENS OF MYCOBACTERIUM LEPRAE FOR DETECTION OF THIS MICRO-ORGANISM IN IRANIAN LEPROSY PATIENTS BY PCR. IRANIAN JOURNAL OF DERMATOLOGY, 8(5 (33)), 388-393. SID. https://sid.ir/paper/57931/en

Vancouver: Copy

SADEGHI V., MAGHSOUDI N., DOULATI Y., DELDAR A.A., HEYDARI SERAJ M.. USE OF 18 AND 36 KDA ANTIGENS OF MYCOBACTERIUM LEPRAE FOR DETECTION OF THIS MICRO-ORGANISM IN IRANIAN LEPROSY PATIENTS BY PCR. IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2005;8(5 (33)):388-393. Available from: https://sid.ir/paper/57931/en

IEEE: Copy

V. SADEGHI, N. MAGHSOUDI, Y. DOULATI, A.A. DELDAR, and M. HEYDARI SERAJ, “USE OF 18 AND 36 KDA ANTIGENS OF MYCOBACTERIUM LEPRAE FOR DETECTION OF THIS MICRO-ORGANISM IN IRANIAN LEPROSY PATIENTS BY PCR,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 8, no. 5 (33), pp. 388–393, 2005, [Online]. Available: https://sid.ir/paper/57931/en

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