MAST CELLS AND HISTOPATHOLOGIC VARIANTS OF BASAL CELL CARCINOMA

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TAYEBI MEYBODI N.; JAVIDI Z.; ESMAEILI H.A.; NAHIDI Y.

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Journal: Iranian Journal of Dermatology Year:2007 | Volume:10 | Issue:2 (40) Page(s): 135-141

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Title

MAST CELLS AND HISTOPATHOLOGIC VARIANTS OF BASAL CELL CARCINOMA

Author(s)

TAYEBI MEYBODI N. | JAVIDI Z. | ESMAEILI H.A. | NAHIDI Y. | Issue Writer Certificate

Keywords

MAST CELLSQ4

BASAL CELL CARCINOMAQ3

INFLAMMATIONQ3

Abstract

Background and aim: The stroma of BASAL CELL CARCINOMA (BCC) is rich in MAST CELLS. Morpheaform BCC has been reported to contain much more MAST CELLS than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of MAST CELLS related to BCC and possible relationship between increased number of MAST CELLS and clinical and histological parameters including the patient's age, sex, subtype of BCC and severity of peritumoral INFLAMMATION.Materials and methods: In this retrospective study, a total of 50 BCC specimens either biopsied or excised were examined histologically. H & E stained slides were examined under light microscopy and the severity of INFLAMMATION was assessed subjectively and graded as mild, moderate or severe. Then biopsy specimens were stained with Giesma to identify MAST CELLS. Clinical data including sex and age were obtained form patients records. Finally the data were analysed by t test, Mann-Whitney and ANOVA by SPSS software and p<0.05 was considered as significant.Results: Superficial forms of BCC had more MAST CELLS than did the deep subtypes (p=0.02). Although it was not statistically significant, but nodulocystic variant of BCC had less MAST CELLS than other types. No significant relationship was found between the number of MAST CELLS and the degree of peritumoral INFLAMMATION, age and gender. Conclusion: Our results support previous reports indicating that MAST CELLS may have a contributory role in defining the subtype of BCC and degree of its aggressiveness. It seems that MAST CELLS have a preventive role against aggression of BCC, as we found more MAST CELLS in superficial BCC than deep ones.

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APA: Copy

TAYEBI MEYBODI, N., JAVIDI, Z., ESMAEILI, H.A., & NAHIDI, Y.. (2007). MAST CELLS AND HISTOPATHOLOGIC VARIANTS OF BASAL CELL CARCINOMA. IRANIAN JOURNAL OF DERMATOLOGY, 10(2 (40)), 135-141. SID. https://sid.ir/paper/57967/en

Vancouver: Copy

TAYEBI MEYBODI N., JAVIDI Z., ESMAEILI H.A., NAHIDI Y.. MAST CELLS AND HISTOPATHOLOGIC VARIANTS OF BASAL CELL CARCINOMA. IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2007;10(2 (40)):135-141. Available from: https://sid.ir/paper/57967/en

IEEE: Copy

N. TAYEBI MEYBODI, Z. JAVIDI, H.A. ESMAEILI, and Y. NAHIDI, “MAST CELLS AND HISTOPATHOLOGIC VARIANTS OF BASAL CELL CARCINOMA,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 10, no. 2 (40), pp. 135–141, 2007, [Online]. Available: https://sid.ir/paper/57967/en

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