ZINGIBER OFFICINALE ALTERS 3,4-METHYLENEDIOXYMETHAMPHETAMINE-INDUCED NEUROTOXICITY IN RAT BRAIN

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MEHDIZADEH MEHDI; DABAGHIAN FATANEH; NEJHADI AKRAM; FALLAH HUSEINI HASSAN; CHOOPANI SAMIRA; SHEKARRIZ NIMA; MOLAVI NIMA; BASIRAT ARGHAVAN; MOHAMMADZADEH KAZORGAH FARZANEH; SAMZADEH KERMANI ALIREZA; SOLEIMANI ASL SARA

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Journal: Cell Journal (Yakhteh) Year:2012 | Volume:14 | Issue:3 (55) Page(s): 177-184

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Title

ZINGIBER OFFICINALE ALTERS 3,4-METHYLENEDIOXYMETHAMPHETAMINE-INDUCED NEUROTOXICITY IN RAT BRAIN

Author(s)

Keywords

APOPTOSIS

GINGER

SPATIAL MEMORY

MDMA

HIPPOCAMPUS

BCL-2 FAMILY

Abstract

Objective: The spice Zingiber officinale or GINGER possesses antioxidant activity and neuroprotective effects. The effects of this traditional herbal medicine on 3, 4-methylenediox ymethamphetamine (MDMA) induced neurotoxicity have not yet been studied. The present study considers the effects of Zingiber officinale on MDMA-induced SPATIAL MEMORY impairment and APOPTOSIS in the HIPPOCAMPUS of male rats.Materials and Methods: In this experimental study, 21 adult male Sprague Dawley rats (200-250 g) were classified into three groups (control, MDMA, and MDMA plus GINGER). The groups were intraperitoneally administered 10 mg/kg MDMA, 10 mg/kg MDMA plus 100 mg/kg GINGER extract, or 1 cc/kg normal saline as the control solution for one week (n=7 per group). Learning memory was assessed by Morris water maze (MWM) after the last administration. Finally, the brains were removed to study the cell number in the cornu ammonis (CA1) HIPPOCAMPUS by light microscope, Bcl-2 by immunoblotting, and Bax expression by reverse transcription polymerase chain reaction (RT-PCR). Data was analyzed using SPSS 16 software and a one-way ANOVA test.Results: Escape latency and traveled distances decreased significantly in the MDMA plus GINGER group relative to the MDMA group (p<0.001). Cell number increased in the MDMA plus GINGER group in comparison to the MDMA group.Down-regulation of Bcl-2 and up-regulation of Bax were observed in the MDMA plus GINGER group in comparison to the MDMA group (p<0.05).Conclusion: Our findings suggest that GINGER consumption may lead to an improvement of MDMA-induced neurotoxicity.

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APA: Copy

MEHDIZADEH, MEHDI, DABAGHIAN, FATANEH, NEJHADI, AKRAM, FALLAH HUSEINI, HASSAN, CHOOPANI, SAMIRA, SHEKARRIZ, NIMA, MOLAVI, NIMA, BASIRAT, ARGHAVAN, MOHAMMADZADEH KAZORGAH, FARZANEH, SAMZADEH KERMANI, ALIREZA, & SOLEIMANI ASL, SARA. (2012). ZINGIBER OFFICINALE ALTERS 3,4-METHYLENEDIOXYMETHAMPHETAMINE-INDUCED NEUROTOXICITY IN RAT BRAIN. CELL JOURNAL (YAKHTEH), 14(3 (55)), 177-184. SID. https://sid.ir/paper/582066/en

Vancouver: Copy

MEHDIZADEH MEHDI, DABAGHIAN FATANEH, NEJHADI AKRAM, FALLAH HUSEINI HASSAN, CHOOPANI SAMIRA, SHEKARRIZ NIMA, MOLAVI NIMA, BASIRAT ARGHAVAN, MOHAMMADZADEH KAZORGAH FARZANEH, SAMZADEH KERMANI ALIREZA, SOLEIMANI ASL SARA. ZINGIBER OFFICINALE ALTERS 3,4-METHYLENEDIOXYMETHAMPHETAMINE-INDUCED NEUROTOXICITY IN RAT BRAIN. CELL JOURNAL (YAKHTEH)[Internet]. 2012;14(3 (55)):177-184. Available from: https://sid.ir/paper/582066/en

IEEE: Copy

MEHDI MEHDIZADEH, FATANEH DABAGHIAN, AKRAM NEJHADI, HASSAN FALLAH HUSEINI, SAMIRA CHOOPANI, NIMA SHEKARRIZ, NIMA MOLAVI, ARGHAVAN BASIRAT, FARZANEH MOHAMMADZADEH KAZORGAH, ALIREZA SAMZADEH KERMANI, and SARA SOLEIMANI ASL, “ZINGIBER OFFICINALE ALTERS 3,4-METHYLENEDIOXYMETHAMPHETAMINE-INDUCED NEUROTOXICITY IN RAT BRAIN,” CELL JOURNAL (YAKHTEH), vol. 14, no. 3 (55), pp. 177–184, 2012, [Online]. Available: https://sid.ir/paper/582066/en

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