EFFECT OF INTERMITTENT NORMOBARIC HYPEROXIA AND PKC ACTIVITY ON BLOOD - BRAIN BARRIER (BBB) PERMEABILITY

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ALAVIYAN F.; HAJIZADEH S.; BIGDELY M.R.; JAVAN M.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2012 | Volume:14 | Issue:3 Page(s): 40-50

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Title

EFFECT OF INTERMITTENT NORMOBARIC HYPEROXIA AND PKC ACTIVITY ON BLOOD - BRAIN BARRIER (BBB) PERMEABILITY

Author(s)

ALAVIYAN F. | HAJIZADEH S. | BIGDELY M.R. | JAVAN M. | Issue Writer Certificate

Keywords

CHELERYTHRIN CHLORIDEQ2

STROKEQ2

PRECONDITIONINGQ2

PKCQ2

HYPEROXIAQ2

Abstract

Background and aims: Studies have recently shown that intermittent normobaric HYPEROXIA has a significant therapeutic effect on the treatment of acute ischemia, this effect so-called PRECONDITIONING. In this study intermittent normobaric effect of HYPEROXIA and PKC activity in the BBB permeability and behavioral assessment were evaluated.Methods: In this experimental study 36 wistar rat were divided to 6 groups as follow: normoxi (shem), normoxi + CHEL, normoxi + halt, normoxi + halt + CHEL, hyproxi + halt, hyperoxi + halt + CHEL, (n=6) in each group. Chelerythrin chlorid (CHEL) was used as a systemically inhibitor of PKC.24 hours later, rats were subjected to 60 min of right middle cerebral artery occlusion (MCAO). The HYPEROXIA and normoxia groups were exposed to 95% and 21% respectively, for 4 h/day, 6 continuous days. After 24 h reperfusion, neurological deficit scores and BBB permeability was assessed. Data were analyzed using two way ANOVA and Bonferroni test.Results: PRECONDITIONING with intermittent normobaric HYPEROXIA decreased neurologic deficit scores and BBB permeability. Inhibition of PKC resulted in the increase of neurologic deficit scores; which improved with HYPEROXIA (P<0.001). PKC inhibition, independent of HYPEROXIA improved the BBB function (P<0.001).Conclusion: With the deployment of HYPEROXIA and specific subunits of PKC during the STROKE, stability of BBB integrity and improvement of neurological deficit scores occur.

Cites

Neuroprotective Effects of Stachys Lavandulifolia Hydroalcoholic Extract on Size of Cerebral Ischemia, Blood-Brain Barrier Permeability and Edema Volume in Rat Stroke Model

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APA: Copy

ALAVIYAN, F., HAJIZADEH, S., BIGDELY, M.R., & JAVAN, M.. (2012). EFFECT OF INTERMITTENT NORMOBARIC HYPEROXIA AND PKC ACTIVITY ON BLOOD - BRAIN BARRIER (BBB) PERMEABILITY. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 14(3), 40-50. SID. https://sid.ir/paper/58229/en

Vancouver: Copy

ALAVIYAN F., HAJIZADEH S., BIGDELY M.R., JAVAN M.. EFFECT OF INTERMITTENT NORMOBARIC HYPEROXIA AND PKC ACTIVITY ON BLOOD - BRAIN BARRIER (BBB) PERMEABILITY. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;14(3):40-50. Available from: https://sid.ir/paper/58229/en

IEEE: Copy

F. ALAVIYAN, S. HAJIZADEH, M.R. BIGDELY, and M. JAVAN, “EFFECT OF INTERMITTENT NORMOBARIC HYPEROXIA AND PKC ACTIVITY ON BLOOD - BRAIN BARRIER (BBB) PERMEABILITY,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 3, pp. 40–50, 2012, [Online]. Available: https://sid.ir/paper/58229/en

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