GENOTOXIC EFFECT OF HYDROGEN PEROXIDE ON BONE MARROW ERYTHROCYTES OF FEMALE BALB/C MOUSE

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BAHARARA J.; HADAD F.; SHARIATZADEH M.A.; RAZAVI T.

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Paper Information

Journal: Journal of Shahrekord University of Medical Sciences Year:2008 | Volume:10 | Issue:3 Page(s): 17-22

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Title

GENOTOXIC EFFECT OF HYDROGEN PEROXIDE ON BONE MARROW ERYTHROCYTES OF FEMALE BALB/C MOUSE

Author(s)

BAHARARA J. | HADAD F. | SHARIATZADEH M.A. | RAZAVI T. | Issue Writer Certificate

Keywords

ERYTHROCYTEQ3

GENOTOXICQ2

HYDROGEN PEROXIDEQ3

MICRONUCLEUSQ2

Abstract

Background and aim: HYDROGEN PEROXIDE is a strong oxidant which is being widely used in hairdresser places. GENOTOXIC effect of such substances, referred to as "interaction between gene & environment, is one of the most worrying problems of international health society. On the basis of the wide use of hydrogene peroxide, its capability on induction of chromosomal damages on polychromatic ERYTHROCYTEs of bone marrow of exposed female Balb/C mice was investigated.Methods: The female Balb/C mice were used as experimental model. The mice were divided to three different groups including: control, sham-exposed & experimental groups. The experimental group was exposed to inhalation of 9% oxidant vapor, containing HYDROGEN PEROXIDE, for 2 and 3.5 hours per day for 7 days. Bone marrow cells of exposed as well as control and sham-exposed mice were collected using FCS, and MICRONUCLEUS assay was performed. The chromosomal aberration was investigated by scoring the MICRONUCLEUS containing polychromatic ERYTHROCYTEs. The data was statistically analyzed by t-test.Results: The results showed that mean No. of polychromatic ERYTHROCYTEs in sham-exposed 1 and treated 1 (2 hours exposure to H2O2) were 8.87±1.01 and 5.75±3.05 respectively (P<0.05), and sham-exposed 2 and treated 2 (3.5 hours exposed to H2O2) were 8±2.36 and 42.37±4.8 respectively (P<0.01). Also increasing the exposure treatment time with H2O2 could increase the chromosomal abnormality (P<0.05).Conclusion: Results of this study revealed the GENOTOXIC effects of inhalation of 9% H2O2 on bone marrow cells of female Balb/C mouse.

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