SIGNIFICANCE OF CMV-SEROPOSITIVITY IN THE ALTERATIONS OF 
CD4+ T-CELL SUBSETS AND EXPRESSION OF THEIR PHENOTYPING MARKERS IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA

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POURGHEYSARI B.; BANI TALEBI M.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2010 | Volume:12 | Issue:1 Page(s): 75-83

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Title

SIGNIFICANCE OF CMV-SEROPOSITIVITY IN THE ALTERATIONS OF CD4+ T-CELL SUBSETS AND EXPRESSION OF THEIR PHENOTYPING MARKERS IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA

Author(s)

POURGHEYSARI B. | BANI TALEBI M. | Issue Writer Certificate

Keywords

CYTOKINEQ3

CHRONIC LYMPHOCYTIC LEUKEMIAQ2

CYTOMEGALOVIRUSQ2

T LYMPHOCYTEQ3

Abstract

Background and aim: B-cell CHRONIC LYMPHOCYTIC LEUKEMIA (B-CLL) is a B-cell malignancy which has been associated with a variety of abnormalities in non-malignant T cells. Viral antigens are able to produce profound alterations in T-cells and CYTOMEGALOVIRUS (CMV) has been involved in T-cell abnormalities in healthy elderly individuals. Therefore, the relationship between these changes and CMV was studied in CLL patients. Methods: This was a cross sectional study and included 79 B-CLL patients (41 CMV seropositive and 38 CMV seronegative). The cell counting was done by Coulter cell counter. The T-cell subgroups and cell phenotype were studied by monoclonal antibodies and flow cytometry. The secretion of CYTOKINE was detected by intracellular CYTOKINE staining post stimulation and short time culture. Results: CD8+ and CD4+CD8dim T cell subgroups were significantly more in CMV+ patients than CMV negatives (P<0.01). IFN-g producing T cells were significantly more in CMV+ patients, whereas IL-2 producing T cells were more in CMV- patients (P<0.05 and P<0.01, respectively). A prominent decrease was seen in the expression of CD27, CD28, CD45RA and CCR7 in CMV+ patients, whereas CD45RO and CD57 showed significant rise (P<0.05 and P<0.001, respectively).Conclusion: CMV seropositivity causes broad alterations in T-cells and expression of terminally differentiated phenotype in B-CLL patients. Therefore, such profile in B-CLL is highly related to CMV seropositivity.

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APA: Copy

POURGHEYSARI, B., & BANI TALEBI, M.. (2010). SIGNIFICANCE OF CMV-SEROPOSITIVITY IN THE ALTERATIONS OF CD4⁺ T-CELL SUBSETS AND EXPRESSION OF THEIR PHENOTYPING MARKERS IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 12(1), 75-83. SID. https://sid.ir/paper/58302/en

Vancouver: Copy

POURGHEYSARI B., BANI TALEBI M.. SIGNIFICANCE OF CMV-SEROPOSITIVITY IN THE ALTERATIONS OF CD4⁺ T-CELL SUBSETS AND EXPRESSION OF THEIR PHENOTYPING MARKERS IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;12(1):75-83. Available from: https://sid.ir/paper/58302/en

IEEE: Copy

B. POURGHEYSARI, and M. BANI TALEBI, “SIGNIFICANCE OF CMV-SEROPOSITIVITY IN THE ALTERATIONS OF CD4⁺ T-CELL SUBSETS AND EXPRESSION OF THEIR PHENOTYPING MARKERS IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 12, no. 1, pp. 75–83, 2010, [Online]. Available: https://sid.ir/paper/58302/en

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