STUDY OF -629C/A POLYMORPHISM OF CHOLESTERYL ESTER TRANSFER PROTEIN GENE IN STATIN EFFECTS ON PLASMA HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL

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FAROKHI EFAT; GHATREH SAMANI K.; AMINI S.A.A.; HASHEMZADEH CHALESHTORI M.; MORADI M.T.; AMINI NAJAFABADI H.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2010 | Volume:12 | Issue:2 Page(s): 35-43

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Title

STUDY OF -629C/A POLYMORPHISM OF CHOLESTERYL ESTER TRANSFER PROTEIN GENE IN STATIN EFFECTS ON PLASMA HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL

Author(s)

Keywords

ATORVASTATINQ2

CHOLESTERYL ESTER TRANSFER PROTEIN (CETP)Q3

-629C/AQ2

POLYMORPHISMQ3

LOVASTATINQ3

HDL-CQ3

Abstract

Background and aim: Cholesteryl ester transfer protein (CETP) plays pivotal role in HDL metabolism and in reverse cholesterol transport (RCT) pathway. CETP gene variants such as -629C/A that affect HDL cholesterol directly, modulates CETP gene transcriptional activity. This study was aimed to determine influence of -629C/A POLYMORPHISM of CETP in statin effects with regard to plasma HDL cholesterol levels.Methods: In this descriptive-analytical study, 196 adult patients with LDL-C more than 120mg/dL were divided into two group’s base on LOVASTATIN and ATORVASTATIN using. Lipid profile was measured in all subjects before and after treatment and -629C/A POLYMORPHISM of CETP promoter was studied using polymerase chain reaction/restriction fragment length POLYMORPHISM method. Data were compared with paired t-test and ANOVA in SPSS software.Results: Cholesterol was decreased and HDL was increased in AA genotype more than other genotypes by LOVASTATIN, but ApoA1 was increased in CC genotype. ApoA1 also was increased in CC genotype more than AA or AC genotypes by ATORVASTATIN.Conclusion: In CC genotype, LOVASTATIN and specially ATORVASTATIN increased ApoA1 in HDL particles more than other genotypes. Therefore, treatment with LOVASTATIN and ATORVASTATIN is more effective in patients with CC genotype for raising HDL particles activity.

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APA: Copy

FAROKHI, EFAT, GHATREH SAMANI, K., AMINI, S.A.A., HASHEMZADEH CHALESHTORI, M., MORADI, M.T., & AMINI NAJAFABADI, H.. (2010). STUDY OF -629C/A POLYMORPHISM OF CHOLESTERYL ESTER TRANSFER PROTEIN GENE IN STATIN EFFECTS ON PLASMA HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 12(2), 35-43. SID. https://sid.ir/paper/58311/en

Vancouver: Copy

FAROKHI EFAT, GHATREH SAMANI K., AMINI S.A.A., HASHEMZADEH CHALESHTORI M., MORADI M.T., AMINI NAJAFABADI H.. STUDY OF -629C/A POLYMORPHISM OF CHOLESTERYL ESTER TRANSFER PROTEIN GENE IN STATIN EFFECTS ON PLASMA HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;12(2):35-43. Available from: https://sid.ir/paper/58311/en

IEEE: Copy

EFAT FAROKHI, K. GHATREH SAMANI, S.A.A. AMINI, M. HASHEMZADEH CHALESHTORI, M.T. MORADI, and H. AMINI NAJAFABADI, “STUDY OF -629C/A POLYMORPHISM OF CHOLESTERYL ESTER TRANSFER PROTEIN GENE IN STATIN EFFECTS ON PLASMA HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 12, no. 2, pp. 35–43, 2010, [Online]. Available: https://sid.ir/paper/58311/en

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