Investigating the in vitro toxicity of silica oxide nanoparticles on differentiated neuronal cells (PC12)

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Yektadoost e.; FALAHATI M.; SARI S.; ATTAR F.

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Journal Paper

Paper Information

Journal: Journal of Shahrekord University of Medical Sciences Year:2018 | Volume:20 | Issue:2 Page(s): 51-58

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Information Journal Paper

Title

Investigating the in vitro toxicity of silica oxide nanoparticles on differentiated neuronal cells (PC12)

Author(s)

Yektadoost e. | FALAHATI M. | SARI S. | ATTAR F. | Issue Writer Certificate

Keywords

Silica nanoparticlesQ1

CytotoxicityQ2

ApoptosisQ2

CaspaseQ1

Abstract

Background and aims: Silica oxide nanoparticles (SiO2-NPs) have attracted a great interest in biotechnology and medicinal fields. It has been documented SiO2-NPs can induce Cytotoxicity in normal cells. However, until now, the Cytotoxicity of SiO2-NPs against nervous system cells did not examine. Methods: In this in vitro study, the activities of Caspase-8 and 6 were analyzed in the PC12 cells treated with different concentrations of silica oxide nanoparticles, and was assessed by Elisa plate reader. Data were analyzed using SPSS software, and by One-way ANOVA and Student t-test. Results: The results showed that the Caspase-8 and 6 activities increased in a concentration dependent manner. Indeed, the activity of Caspase-8 and 6 was induced after exposure to 1-100 μ M of SiO2-NPs. However, the SiO2-NPs showed only slight toxicity in the concentration of 0. 1 μ M (P<0. 05). Conclusion: A mitochondrial-dependent pathway activated by Caspase-8 and 6 mediated by SiO2-NPs may be involved in Apoptosis induced by NPs, and therefore, cell Cytotoxicity plays a role in PC12 cells.

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References

TOXICITY OF NANOPARTICLES AND AN OVERVIEW OF CURRENT EXPERIMENTAL MODELS

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APA: Copy

Yektadoost, e., FALAHATI, M., SARI, S., & ATTAR, F.. (2018). Investigating the in vitro toxicity of silica oxide nanoparticles on differentiated neuronal cells (PC12). JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 20(2 ), 51-58. SID. https://sid.ir/paper/58437/en

Vancouver: Copy

Yektadoost e., FALAHATI M., SARI S., ATTAR F.. Investigating the in vitro toxicity of silica oxide nanoparticles on differentiated neuronal cells (PC12). JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;20(2 ):51-58. Available from: https://sid.ir/paper/58437/en

IEEE: Copy

e. Yektadoost, M. FALAHATI, S. SARI, and F. ATTAR, “Investigating the in vitro toxicity of silica oxide nanoparticles on differentiated neuronal cells (PC12),” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 2 , pp. 51–58, 2018, [Online]. Available: https://sid.ir/paper/58437/en

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