MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE WITH METASTATIC CARCINOMA – A RARE PRESENTATION

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JOSEPH KOSHY PRIYANKA; JUSTIN MIJIL ANAND; VEDAVYASAN MEENAKSHI; ALEXANDER THOMAS; VARGHESE RENU GBOY

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Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2012 | Volume:7 | Issue:1 Page(s): 58-62

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Title

MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE WITH METASTATIC CARCINOMA – A RARE PRESENTATION

Author(s)

Keywords

MONOCLONAL GAMMAPATHY OF UNDETERMINED SIGNIFICANCE

METASTASIS

CARCINOMA

Abstract

The presence of a low level of M protein in the peripheral blood<3mg/dl which is below the required cut off for the diagnosis of plasma cell myeloma is known as monoclonal gammopathy of undetermined significance (MGUS). Elevated levels of serum M protein and detection of M band on serum protein electrophoresis (SPE) can occur in chronic diseases not related to B cell disorders and not always diagnostic for B cell dyscrasias. It can also be seen in non hematological malignancies as seen in our case. We present a case of MGUS in a 59yr male patient, previously diagnosed and surgically treated for CARCINOMA prostate and colon. Serum electrophoresis revealed an M Band – monoclonal protein of 1.9 mg/dl. Urine for Bence Jones proteins was negative and his skeletal X-rays did not reveal lytic lesions. Bone marrow aspiration revealed metastatic CARCINOMA.Plasma cells formed 1% of the bone marrow differential count.

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APA: Copy

JOSEPH KOSHY, PRIYANKA, JUSTIN, MIJIL ANAND, VEDAVYASAN, MEENAKSHI, ALEXANDER, THOMAS, & VARGHESE, RENU GBOY. (2012). MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE WITH METASTATIC CARCINOMA – A RARE PRESENTATION. IRANIAN JOURNAL OF PATHOLOGY (IJP), 7(1), 58-62. SID. https://sid.ir/paper/584528/en

Vancouver: Copy

JOSEPH KOSHY PRIYANKA, JUSTIN MIJIL ANAND, VEDAVYASAN MEENAKSHI, ALEXANDER THOMAS, VARGHESE RENU GBOY. MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE WITH METASTATIC CARCINOMA – A RARE PRESENTATION. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2012;7(1):58-62. Available from: https://sid.ir/paper/584528/en

IEEE: Copy

PRIYANKA JOSEPH KOSHY, MIJIL ANAND JUSTIN, MEENAKSHI VEDAVYASAN, THOMAS ALEXANDER, and RENU GBOY VARGHESE, “MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE WITH METASTATIC CARCINOMA – A RARE PRESENTATION,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 7, no. 1, pp. 58–62, 2012, [Online]. Available: https://sid.ir/paper/584528/en

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