EVALUATION OF PSEUDOADRENAL INSUFFICIENCY IN TUBERCULOSIS PATIENTS

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TABARSI P.; BAGHAEI P.; VALI ELAHPOUR AMIRI M.; BARARI M.; MANSOURI S.D.; HEYDARNEZHAD HASAN; VELAYATI A.A.

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Journal: TANAFFOS Year:2007 | Volume:6 | Issue:1 (21) Page(s): 67-70

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Title

EVALUATION OF PSEUDOADRENAL INSUFFICIENCY IN TUBERCULOSIS PATIENTS

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Keywords

PSEUDO-ADRENAL INSUFFICIENCY

ACTIVE TUBERCULOSIS

RIFAMPICIN

Abstract

Background: Adrenal insufficiency following initial treatment of ACTIVE TUBERCULOSIS (TB) is a rare phenomenon. It is also one of the most important causes of mortality within the first few days of TB treatment. The present study evaluated this adverse effect of anti-tuberculous treatment.Materials and Methods: A prospective study was performed on TB patients hospitalized in Masih Daneshvari Hospital between 2004 and 2005. All patients had received standard anti-TB drug regimen. We evaluated PSEUDO-ADRENAL INSUFFICIENCY in these patients.Results: The study group included 429 patients out of which 6(1.4%) developed adrenal insufficiency following anti-TB treatment. In all 6 patients, basal serum cortisol levels were measured which were below the normal range after treatment. No patient had clinical findings of adrenal insufficiency before initiation of anti-TB therapy. After treatment with dexamethasone, the general condition of patients improved. (The average response to treatment was 3.1±1.7 days). No mortality was reported during the treatment course or follow-up period.Conclusion: In TB patients, the adrenal reserve/ serum cortisol reserve level is low. Standard anti-TB drug regimen including RIFAMPICIN causes rapid catabolism of cortisol in tissues specially in the liver and lungs; therefore, serum cortisol level will be more decreased and consequently the patient develops adrenal insufficiency. As a whole, despite of the low incidence rate of this adverse effect, early diagnosis and treatment is essential to save the patient's life.

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APA: Copy

TABARSI, P., BAGHAEI, P., VALI ELAHPOUR AMIRI, M., BARARI, M., MANSOURI, S.D., HEYDARNEZHAD, HASAN, & VELAYATI, A.A.. (2007). EVALUATION OF PSEUDOADRENAL INSUFFICIENCY IN TUBERCULOSIS PATIENTS. TANAFFOS, 6(1 (21)), 67-70. SID. https://sid.ir/paper/584980/en

Vancouver: Copy

TABARSI P., BAGHAEI P., VALI ELAHPOUR AMIRI M., BARARI M., MANSOURI S.D., HEYDARNEZHAD HASAN, VELAYATI A.A.. EVALUATION OF PSEUDOADRENAL INSUFFICIENCY IN TUBERCULOSIS PATIENTS. TANAFFOS[Internet]. 2007;6(1 (21)):67-70. Available from: https://sid.ir/paper/584980/en

IEEE: Copy

P. TABARSI, P. BAGHAEI, M. VALI ELAHPOUR AMIRI, M. BARARI, S.D. MANSOURI, HASAN HEYDARNEZHAD, and A.A. VELAYATI, “EVALUATION OF PSEUDOADRENAL INSUFFICIENCY IN TUBERCULOSIS PATIENTS,” TANAFFOS, vol. 6, no. 1 (21), pp. 67–70, 2007, [Online]. Available: https://sid.ir/paper/584980/en

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