IN VITRO STUDY OF OXALI-PALLADIUM EFFECT ON HUMAN HEMOGLOBIN

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ABBASI TEJARAG KH.; DIVSALAR A.; SABOURY A.A.; ESLAMI MOGHADM M.; POURSASAN N.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2014 | Volume:16 | Issue:4 Page(s): 110-119

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Title

IN VITRO STUDY OF OXALI-PALLADIUM EFFECT ON HUMAN HEMOGLOBIN

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Keywords

HEME DEGRADATIONQ2

OXALI-PALLADIUMQ2

HUMAN HEMOGLOBINQ2

ANEMIAQ3

ULTRAVIOLET SPECTROSCOPYQ2

Abstract

Background and aims: Background and aim: Platinum-based drugs cause heme group to be released from hemoglobin through binding to hemoglobin, impair hemoglobin function and thereby develop ANEMIA in the patient under treatment. The aim of the present study was to examine side effects of OXALI-PALLADIUM as a new synthetic anticancer drug through interacting with hemoglobin and degrading heme group.Methods: In this experimental study, HUMAN HEMOGLOBIN structure was studied in vitro in presence and absence of OXALI-PALLADIUM. For study of structural variations and degradation of heme, hemoglobin absorbance spectrum was examined at 200 to 700-nm wavelengths. Also, for more accurate study of variations in three-dimensional structure of hemoglobin and the possibility of HEME DEGRADATION, spectroscopic examination of fluorescence was done at two ambient and physiological temperatures.Results: Addition of OXALI-PALLADIUM at different concentrations into hemoglobin caused increase in absorbance at 280-nm wavelength and decrease in absorbance at 415-nm wavelength (corresponding to peak Surat). Also, it caused a pronounced decrease in intensity of intrinsic fluorescence emission and increase in fluorescence emission intensity of the products derived from HEME DEGRADATION in hemoglobin at both studied temperatures.Conclusion: By the findings of this study, OXALI-PALLADIUM causes structural and functional variations in hemoglobin through heme isolation and degradation and hence could develop ANEMIA in patients under treatment.

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APA: Copy

ABBASI TEJARAG, KH., DIVSALAR, A., SABOURY, A.A., ESLAMI MOGHADM, M., & POURSASAN, N.. (2014). IN VITRO STUDY OF OXALI-PALLADIUM EFFECT ON HUMAN HEMOGLOBIN. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 16(4), 110-119. SID. https://sid.ir/paper/58769/en

Vancouver: Copy

ABBASI TEJARAG KH., DIVSALAR A., SABOURY A.A., ESLAMI MOGHADM M., POURSASAN N.. IN VITRO STUDY OF OXALI-PALLADIUM EFFECT ON HUMAN HEMOGLOBIN. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;16(4):110-119. Available from: https://sid.ir/paper/58769/en

IEEE: Copy

KH. ABBASI TEJARAG, A. DIVSALAR, A.A. SABOURY, M. ESLAMI MOGHADM, and N. POURSASAN, “IN VITRO STUDY OF OXALI-PALLADIUM EFFECT ON HUMAN HEMOGLOBIN,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 4, pp. 110–119, 2014, [Online]. Available: https://sid.ir/paper/58769/en

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