مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

350
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

221
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

2

Information Journal Paper

Title

THE ROLE OF THE A2A RECEPTOR IN CELL APOPTOSIS CAUSED BY MDMA

Pages

  231-236

Abstract

 Objective: Ecstasy, also known as 3, 4-methylenedioxymethamphetamine (MDMA), is a psychoactive recreational hallucinogenic substance and a major worldwide recreational drug.There are neurotoxic effects observed in laboratory animals and humans following MDMA use. MDMA causes apoptosis in neurons of the central nervous system (CNS). Withdrawal signs are attenuated by treatment with the ADENOSINE RECEPTOR (A2A receptor). This study reports the effects of glutamyl cysteine synthetase (GCS), as an A2A receptor agonist, and succinylcholine (SCH), as an A2A receptor antagonist, on Sprague Dawley rats, both in the presence and absence of MDMA.Materials and Methods: In this experimental study, we used seven groups of Sprague Dawley rats (200-250 g each). Each group was treated with daily intraperitoneal (IP) injections for a period of one week, as follows: i. MDMA (10 mg/kg); ii.GCS (0.3 mg/kg); iii. SCH (0.3 mg/kg); iv. GCS+SCH (0.3 mg/kg each); v. MDMA (10 mg/kg) +GCS (0.3 mg/kg); vi. MDMA (10 mg/kg) +SCH (0.3 mg/kg); and vi.normal saline (1 cc/kg) as the sham group. Bax (apoptotic protein) and Bcl-2 (anti-apoptotic protein) expressions were evaluated by striatum using RT-PCR and Western blot analysis.Results: There was a significant increase in Bax protein expression in the MDMA+SCH group and a significant decrease in Bcl-2 protein expression in the MDMA+SCH group (p<0.05).Conclusion: A2A receptors have a role in the apoptotic effects of MDMA via the Bax and Bcl-2 pathways. An agonist of this receptor (GCS) decreases the cytotoxcity of MDMA, while the antagonist of this receptor (SCH) increases its cytotoxcity.

Cites

References

  • No record.

    • Cite

    APA: Copy

    SOLEIMANI, MANSOOREH, KATEBI, MAJID, ALIZADEH, AKRAM, MOHAMMADZADEH, FARZANEH, & MEHDIZADEH, MEHDI. (2012). THE ROLE OF THE A2A RECEPTOR IN CELL APOPTOSIS CAUSED BY MDMA. CELL JOURNAL (YAKHTEH), 14(3 (55)), 231-236. SID. https://sid.ir/paper/590385/en

    Vancouver: Copy

    SOLEIMANI MANSOOREH, KATEBI MAJID, ALIZADEH AKRAM, MOHAMMADZADEH FARZANEH, MEHDIZADEH MEHDI. THE ROLE OF THE A2A RECEPTOR IN CELL APOPTOSIS CAUSED BY MDMA. CELL JOURNAL (YAKHTEH)[Internet]. 2012;14(3 (55)):231-236. Available from: https://sid.ir/paper/590385/en

    IEEE: Copy

    MANSOOREH SOLEIMANI, MAJID KATEBI, AKRAM ALIZADEH, FARZANEH MOHAMMADZADEH, and MEHDI MEHDIZADEH, “THE ROLE OF THE A2A RECEPTOR IN CELL APOPTOSIS CAUSED BY MDMA,” CELL JOURNAL (YAKHTEH), vol. 14, no. 3 (55), pp. 231–236, 2012, [Online]. Available: https://sid.ir/paper/590385/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button