EFFICACY OF CHLORAL HYDRATE AND PROMETHAZINE FOR SEDATION DURING ELECTROENCEPHALOGRAPHY IN CHILDREN: A RANDOMISED CLINICAL TRIAL

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FALLAH RAZIEH; JALILI SHARAM; GOLESTAN MOTAHHAREH; AKHAVAN KARBASI SEDIGHAH; JARAHZADEH MOHAMMAD HOSSEIN

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Journal: Iranian Journal of Pediatrics Year:2013 | Volume:23 | Issue:1 Page(s): 27-31

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Title

EFFICACY OF CHLORAL HYDRATE AND PROMETHAZINE FOR SEDATION DURING ELECTROENCEPHALOGRAPHY IN CHILDREN: A RANDOMISED CLINICAL TRIAL

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Keywords

CHLORAL HYDRATE

PROMETHAZINE

EEG

CHILDREN

SEDATION

Abstract

Objective: Electroencephalography (EEG) is useful in seizure diagnosis. The purpose of this study was to compare efficacy and safety of oral CHLORAL HYDRATE (CH) and PROMETHAZINE (PZ) in SEDATION induction for EEG of CHILDREN.Methods: In a parallel single-blinded randomized clinical trial, sixty 1-10 year old CHILDREN referred to EEG Unit of Shahid Sadoughi Hospital from January 2010 to February 2011 in Yazd- Iran, were evaluated They were randomized to receive orally 70 mg/kg CHLORAL HYDRATE or PROMETHAZINE 1 mg/kg. The primary outcomes were efficacy in adequate SEDATION and successful recording of EEG. Secondary outcomes included clinical side effects, time from administration of the drug to adequate SEDATION, caregiver’s satisfaction on a likert scale (1-5), and total stay time in EEG unit.Findings: Twenty four girls (40%) and 36 boys (60%) with mean age of 2.9±1.9 years were evaluated. Adequate SEDATION (Ramsay SEDATION score of four) was obtained in 43.3 % of PZ and 100% of CH group (p=0.00001). Also in 70% of PZ and 96.7% of CH group, EEG was successfully recorded (p=0.006). So, CH was a more effective drug. In CH group, EEG was performed in shorter time after taking the drug (mean± SD: 32.82±9.6 minutes vs. 52.14±22.88 minutes, P=0.0001) and the parents waited less in the EEG unit (mean±SD: 1.29±0.54 hours vs. 2.6±0.59 hours, P=0.0001). They were also more satisfied (mean±SD: 4.6±0.6 scores vs. 3.1±1.4 scores, P=0.001). Mild side effects such as vomiting in 20% of CH (N=6) and agitation in 6.6% of PZ group (N=2) were seen. No significant difference was seen from viewpoint of side effects frequency between the two drugs.Conclusion: The results of the present study, showed that CHLORAL HYDRATE can be considered as a safe and more effective drug in SEDATION induction for sleep EEG in CHILDREN.

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Oral Midazolam Vs Promethazine as Pre Sedation Medication in Pediatric Dentistry

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APA: Copy

FALLAH, RAZIEH, JALILI, SHARAM, GOLESTAN, MOTAHHAREH, AKHAVAN KARBASI, SEDIGHAH, & JARAHZADEH, MOHAMMAD HOSSEIN. (2013). EFFICACY OF CHLORAL HYDRATE AND PROMETHAZINE FOR SEDATION DURING ELECTROENCEPHALOGRAPHY IN CHILDREN: A RANDOMISED CLINICAL TRIAL. IRANIAN JOURNAL OF PEDIATRICS, 23(1), 27-31. SID. https://sid.ir/paper/590784/en

Vancouver: Copy

FALLAH RAZIEH, JALILI SHARAM, GOLESTAN MOTAHHAREH, AKHAVAN KARBASI SEDIGHAH, JARAHZADEH MOHAMMAD HOSSEIN. EFFICACY OF CHLORAL HYDRATE AND PROMETHAZINE FOR SEDATION DURING ELECTROENCEPHALOGRAPHY IN CHILDREN: A RANDOMISED CLINICAL TRIAL. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2013;23(1):27-31. Available from: https://sid.ir/paper/590784/en

IEEE: Copy

RAZIEH FALLAH, SHARAM JALILI, MOTAHHAREH GOLESTAN, SEDIGHAH AKHAVAN KARBASI, and MOHAMMAD HOSSEIN JARAHZADEH, “EFFICACY OF CHLORAL HYDRATE AND PROMETHAZINE FOR SEDATION DURING ELECTROENCEPHALOGRAPHY IN CHILDREN: A RANDOMISED CLINICAL TRIAL,” IRANIAN JOURNAL OF PEDIATRICS, vol. 23, no. 1, pp. 27–31, 2013, [Online]. Available: https://sid.ir/paper/590784/en

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