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Information Journal Paper

Title

SEROPREVALENCE OF IGG ANTIBODIES AGAINST BORDETELLA PERTUSSIS IN DIFFERENT AGE GROUPS IN TEHRAN, IRAN

Pages

  171-176

Abstract

 Background and Aims: Pertussis is a highly contagious, vaccine-preventable disease. Determination of the SEROEPIDEMIOLOGY of pertussis makes possible the evaluation of pertussis immunity in a population. In this study, we determined the seroprevalence of BORDETELLA PERTUSSIS IgG antibodies in different age groups in Tehran, IRAN.Materials and Methods: Overall, 1101 subjects between ages of 8 months and 20 years were tested for the presence of pertussis toxin (PT), filamentous hemagglutinin (FHA) and different lipopolysaccharides (LPS) antibodies by ELISA.Results: The overall prevalence of pertussis antibodies was 48% and the mean antibody level was 44 ± 47.7 U/ml. Over half (53.1%) of the children aged 8 months to 6 years were negative for pertussis antibodies. Pertussis antibodies rates and levels were significantly different between age groups (P<0.001) and their significant elevations were observed with increasing age.Conclusion: Up to half of the vaccinated children lacked an antibody response to vaccine, so using a more immunogenically effective vaccine to ensure sufficient immunity is essential. We showed that B. pertussis infection is on the rise in IRANian adolescents and young adults. Booster vaccination of this age group appears to be the most logical approach to disease prevention in adolescents and control the circulation of the organism.

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    APA: Copy

    ESLAMIFAR, ALI, RAMEZANI, AMITIS, BANIFAZL, MOHAMMAD, KHADEM SADEGH, AKBAR, & AGHAKHANI, AREZOO. (2012). SEROPREVALENCE OF IGG ANTIBODIES AGAINST BORDETELLA PERTUSSIS IN DIFFERENT AGE GROUPS IN TEHRAN, IRAN. IRANIAN JOURNAL OF PATHOLOGY (IJP), 7(3), 171-176. SID. https://sid.ir/paper/590962/en

    Vancouver: Copy

    ESLAMIFAR ALI, RAMEZANI AMITIS, BANIFAZL MOHAMMAD, KHADEM SADEGH AKBAR, AGHAKHANI AREZOO. SEROPREVALENCE OF IGG ANTIBODIES AGAINST BORDETELLA PERTUSSIS IN DIFFERENT AGE GROUPS IN TEHRAN, IRAN. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2012;7(3):171-176. Available from: https://sid.ir/paper/590962/en

    IEEE: Copy

    ALI ESLAMIFAR, AMITIS RAMEZANI, MOHAMMAD BANIFAZL, AKBAR KHADEM SADEGH, and AREZOO AGHAKHANI, “SEROPREVALENCE OF IGG ANTIBODIES AGAINST BORDETELLA PERTUSSIS IN DIFFERENT AGE GROUPS IN TEHRAN, IRAN,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 7, no. 3, pp. 171–176, 2012, [Online]. Available: https://sid.ir/paper/590962/en

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