CYNARA SCOLYMUS L. IN TREATMENT OF HYPERCHOLESTEROLEMIC TYPE 2 DIABETIC PATIENTS: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED CLINICAL TRIAL

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FALLAH HUSEINI H.; KIANBAKHT S.; HESHMAT R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Medicinal Plants Year:2012 | Volume:11 | Issue:41 Page(s): 58-65

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Title

CYNARA SCOLYMUS L. IN TREATMENT OF HYPERCHOLESTEROLEMIC TYPE 2 DIABETIC PATIENTS: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED CLINICAL TRIAL

Author(s)

FALLAH HUSEINI H. | KIANBAKHT S. | HESHMAT R. | Issue Writer Certificate

Keywords

ARTICHOKE

HYPERLIPIDEMIA

PATIENT

TYPE 2 DIABETES

Abstract

Background: TYPE 2 DIABETES mellitus with HYPERLIPIDEMIA is a common disease. Conventional anti-hyperglycemic and anti-hyperlipidemic drugs have limited efficacies and important side effects, so that alternative agents are needed. Previous studies suggest that fiber-free ARTICHOKE (Cynara scolymus L.) leaf extract may have anti-hyperglycemic and anti-hypercholesterolemic effects in hypercholesterolemic type 2 diabetic PATIENTs. Moreover, ARTICHOKE leaves are used traditionally as an anti-hyperglycemic and anti-hyperlipidemic remedy to treat diabetes mellitus and HYPERLIPIDEMIA.Objective: The effects of ARTICHOKE leaf extract in treatment of hypercholesterolemic type 2 diabetic PATIENTs were studied.Methods: In this randomized double-blind placebo-controlled clinical trial with hypercholesterolemic type 2 diabetic PATIENTs aged 40 to 60 years not using other antihyperlipidemic agents and resistant to daily intake of two 5 mg glyburide tablets and two 500 mg metformin tablets, the efficacy and safety of taking fiber-free ARTICHOKE leaf extract (one 400 mg capsule t.i.d. for 2 months) combined with the aforementioned drugs in treatment of 36 PATIENTs were evaluated and compared with the placebo group (n=36).Results: The extract lowered the blood levels of total cholesterol and LDL cholesterol significantly (P=0.002 and p=0.040 respectively) without any significant effects on the blood levels of fasting glucose, postprandial glucose, glycosylated hemoglobin, other lipids, SGOT, SGPT and creatinine (P>0.05) compared with placebo at the endpoint. No adverse effects were reported.Conclusion: Fiber-free ARTICHOKE extract may be a safe anti-hypercholesterolemic agent but does not improve glycemic control in hypercholesterolemic type 2 diabetic PATIENTs, suggesting the involvement of fibers in the anti-hyperglycemic effect of ARTICHOKE.

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APA: Copy

FALLAH HUSEINI, H., KIANBAKHT, S., & HESHMAT, R.. (2012). CYNARA SCOLYMUS L. IN TREATMENT OF HYPERCHOLESTEROLEMIC TYPE 2 DIABETIC PATIENTS: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED CLINICAL TRIAL. JOURNAL OF MEDICINAL PLANTS, 11(41), 58-65. SID. https://sid.ir/paper/590967/en

Vancouver: Copy

FALLAH HUSEINI H., KIANBAKHT S., HESHMAT R.. CYNARA SCOLYMUS L. IN TREATMENT OF HYPERCHOLESTEROLEMIC TYPE 2 DIABETIC PATIENTS: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED CLINICAL TRIAL. JOURNAL OF MEDICINAL PLANTS[Internet]. 2012;11(41):58-65. Available from: https://sid.ir/paper/590967/en

IEEE: Copy

H. FALLAH HUSEINI, S. KIANBAKHT, and R. HESHMAT, “CYNARA SCOLYMUS L. IN TREATMENT OF HYPERCHOLESTEROLEMIC TYPE 2 DIABETIC PATIENTS: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED CLINICAL TRIAL,” JOURNAL OF MEDICINAL PLANTS, vol. 11, no. 41, pp. 58–65, 2012, [Online]. Available: https://sid.ir/paper/590967/en

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