COMPARISON OF PROPHYLACTIC USE OF MEPERIDINE AND TWO LOW DOSES OF KETAMINE FOR PREVENTION OF POST-ANESTHETIC SHIVERING: A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED TRIAL

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AYATOLLAHI VIDA; HAJIESMAEILI MOHAMMAD REZA; BEHDAD SHEKOUFEH; GHOLIPUR MOHAMMAD; ABBASI HAMID REZA

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2011 | Volume:16 | Issue:10 Page(s): 1340-1346

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Title

COMPARISON OF PROPHYLACTIC USE OF MEPERIDINE AND TWO LOW DOSES OF KETAMINE FOR PREVENTION OF POST-ANESTHETIC SHIVERING: A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED TRIAL

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Keywords

POSTANESTHETIC SHIVERING

MEPERIDINE

KETAMINE

Abstract

BACKGROUND: POSTANESTHETIC SHIVERING is one of the most common complications of anesthesia. We compared the efficacy of MEPERIDINE and two low doses of KETAMINE with placebo to prevent POSTANESTHETIC SHIVERING after general anesthesia.METHODS: This was a prospective, randomized double-blind placebo controlled clinical trial involving 120 ASA I-II patients aging 20-50 years, undergoing endoscopic sinus surgery with general anesthesia. Patients were randomly allocated to receive MEPERIDINE 0.4 mg/kg (Group M, n=30), KETAMINE 0.3 mg/kg (Group K1, n=30), KETAMINE 0.5 mg/kg (Group K2, n=30), or normal saline (Group N, n=30) 20 minutes before completion of the surgery. Tympanic temperature, blood pressure, and heart rate were measured before and immediately after induction of anesthesia, 30 minutes after induction, and before administration of the study drugs. The drugs were prepared and diluted to a volume of 2 ml and presented as coded syringes. An investigator, blinded to the groups, graded POSTANESTHETIC SHIVERING using a fourpoint scale. Statistical analyses were performed using Statistical Package for Social Sciences (SPSS) Windows version 16. A p-value<0.05 was considered statistically significant.RESULTS: Patient characteristics of the four groups were similar. The number of patients with observed shivering in groups was 0, 3, 1, and 9 in Groups M, K1, K2 and N, respectively. The difference between groups M, K1, and K2 with Group N was statistically significant. However, differences between groups M and K1, M and K2, and K1 and K2 were not significant. The number of patients with a shivering score of 2 or 3 was higher in Group N compared with other groups.CONCLUSIONS: Prophylactic use of low doses of intravenous KETAMINE (0.3 or 0.5 mg/kg) was found to be effective to prevent POSTANESTHETIC SHIVERING. However, administration of 0.3 mg/kg KETAMINE lowered the rate of hallucination as compared with 0.5 mg/kg.

Cites

PREVENTION OF SHIVERING DURING REGIONAL ANESTHESIA IN CESAREAN SECTION: COMPARISON OF THE TWO DIFFERENT DOSES OF KETAMINE AND PLACEBO

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APA: Copy

AYATOLLAHI, VIDA, HAJIESMAEILI, MOHAMMAD REZA, BEHDAD, SHEKOUFEH, GHOLIPUR, MOHAMMAD, & ABBASI, HAMID REZA. (2011). COMPARISON OF PROPHYLACTIC USE OF MEPERIDINE AND TWO LOW DOSES OF KETAMINE FOR PREVENTION OF POST-ANESTHETIC SHIVERING: A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 16(10), 1340-1346. SID. https://sid.ir/paper/591157/en

Vancouver: Copy

AYATOLLAHI VIDA, HAJIESMAEILI MOHAMMAD REZA, BEHDAD SHEKOUFEH, GHOLIPUR MOHAMMAD, ABBASI HAMID REZA. COMPARISON OF PROPHYLACTIC USE OF MEPERIDINE AND TWO LOW DOSES OF KETAMINE FOR PREVENTION OF POST-ANESTHETIC SHIVERING: A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2011;16(10):1340-1346. Available from: https://sid.ir/paper/591157/en

IEEE: Copy

VIDA AYATOLLAHI, MOHAMMAD REZA HAJIESMAEILI, SHEKOUFEH BEHDAD, MOHAMMAD GHOLIPUR, and HAMID REZA ABBASI, “COMPARISON OF PROPHYLACTIC USE OF MEPERIDINE AND TWO LOW DOSES OF KETAMINE FOR PREVENTION OF POST-ANESTHETIC SHIVERING: A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED TRIAL,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 16, no. 10, pp. 1340–1346, 2011, [Online]. Available: https://sid.ir/paper/591157/en

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