DETECTION OF PARTIAL DELETIONS OF Y-CHROMOSOME AZFC IN INFERTILE MEN USING THE MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION ASSAY (SHORT COMMUNICATION)

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BUNYAN DAVID J.; CALLAWAY JONATHAN L.A.; LADDACH NADJA

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Journal Paper

Paper Information

Journal: Journal of Reproduction & Infertility Year:2012 | Volume:13 | Issue:3 (52) Page(s): 174-178

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Information Journal Paper

Title

DETECTION OF PARTIAL DELETIONS OF Y-CHROMOSOME AZFC IN INFERTILE MEN USING THE MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION ASSAY (SHORT COMMUNICATION)

Author(s)

BUNYAN DAVID J. | CALLAWAY JONATHAN L.A. | LADDACH NADJA | Issue Writer Certificate

Keywords

CAUSALITY

GENE DOSAGE

INFERTILITY

MICRO DELETIONS

MOLECULAR GENETICS

Y-CHROMOSOME

Abstract

Background: In recent studies, partial deletions of the azoospermia factor c region (AZFc) on the Y-CHROMOSOME have been detected in males with INFERTILITY problems.However, there has been a lot of debate about their significance. In order to study such deletions, a simple but accurate method for their detection was applied in this study.Methods: We present data obtained from the Multiplex Ligation-dependent Probe Amplification (MLPA) assay using a new Y-CHROMOSOME-specific MLPA probemix (P360) which allows the easy detection of partial AZFc deletions.Results: Partial AZFc deletions were detected in 8% of our cohort of previously mutation-negative infertile males (and 0% of the fertile control cohort).Conclusion: These results provide further evidence of the CAUSALITY of partial AZFc deletions. None of the partial AZFc deletions were detectable by the standard multiplex PCR method, demonstrating the advantage of the MLPA method.

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APA: Copy

BUNYAN, DAVID J., CALLAWAY, JONATHAN L.A., & LADDACH, NADJA. (2012). DETECTION OF PARTIAL DELETIONS OF Y-CHROMOSOME AZFC IN INFERTILE MEN USING THE MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION ASSAY (SHORT COMMUNICATION). JOURNAL OF REPRODUCTION AND INFERTILITY, 13(3 (52)), 174-178. SID. https://sid.ir/paper/592912/en

Vancouver: Copy

BUNYAN DAVID J., CALLAWAY JONATHAN L.A., LADDACH NADJA. DETECTION OF PARTIAL DELETIONS OF Y-CHROMOSOME AZFC IN INFERTILE MEN USING THE MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION ASSAY (SHORT COMMUNICATION). JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2012;13(3 (52)):174-178. Available from: https://sid.ir/paper/592912/en

IEEE: Copy

DAVID J. BUNYAN, JONATHAN L.A. CALLAWAY, and NADJA LADDACH, “DETECTION OF PARTIAL DELETIONS OF Y-CHROMOSOME AZFC IN INFERTILE MEN USING THE MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION ASSAY (SHORT COMMUNICATION),” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 13, no. 3 (52), pp. 174–178, 2012, [Online]. Available: https://sid.ir/paper/592912/en

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