EFFECT OF ERYTHROPOIETIN ON GLASGOW COMA SCALE AND GLASGOW OUTCOME SCALE IN PATIENT WITH DIFFUSE AXONAL INJURY

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ABRISHAMKAR SAEID; SAFAVI MOHAMMADREZA; HONARMAND AZIM

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2011 | Volume:17 | Issue:1 Page(s): 51-56

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Title

EFFECT OF ERYTHROPOIETIN ON GLASGOW COMA SCALE AND GLASGOW OUTCOME SCALE IN PATIENT WITH DIFFUSE AXONAL INJURY

Author(s)

ABRISHAMKAR SAEID | SAFAVI MOHAMMADREZA | HONARMAND AZIM | Issue Writer Certificate

Keywords

ERYTHROPOIETIN

OUTCOME

DIFFUSE AXONAL INJURY

Abstract

BACKGROUND: ERYTHROPOIETIN (EPO) as a major stimulator of red blood cell (RBC) production play a key role on brain protection and have a caring effect on neurons from hypoxic or traumatic injury. The objective of this trial was to study the safety and efficacy of recombinant human EPO (rhEPO) on level of consciousness and other OUTCOMEs in patient with post traumatic DIFFUSE AXONAL INJURY (PTDAI).METHODS: In a controlled double-blind randomized clinical trial, 54 patients aged 20-47 years were randomly allocated to 2 groups. Subjects in intervention group (n=27) received 2000U open-label rhEPO (ERYTHROPOIETIN-b; Roche, Grenzach- Wyhlen, Germany) subcutaneously for six doses in two weeks (on days: 2, 4, 6, 8 and 10). The efficacies of the intervention were evaluated by GCS (Glasgow Coma Scale) and GOS (Glasgow OUTCOME Scale).RESULTS: The patients that were treated by rhEPO improved earlier with the difference between the treatment groups occurring on the day 10 (score differences of 9.6 for GCS and 1.9 for GOS). The better course of the rhEPO-treated patients continued throughout the remaining study period. The hematocrit and red blood cell counts did not increase to levels exceeding the normal range in rhEPO patients.CONCLUSIONS: Intravenous EPO was well tolerated in DIFFUSE AXONAL INJURY and was associated with an improvement in patients’ OUTCOME in 2 weeks.

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APA: Copy

ABRISHAMKAR, SAEID, SAFAVI, MOHAMMADREZA, & HONARMAND, AZIM. (2011). EFFECT OF ERYTHROPOIETIN ON GLASGOW COMA SCALE AND GLASGOW OUTCOME SCALE IN PATIENT WITH DIFFUSE AXONAL INJURY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 17(1), 51-56. SID. https://sid.ir/paper/593708/en

Vancouver: Copy

ABRISHAMKAR SAEID, SAFAVI MOHAMMADREZA, HONARMAND AZIM. EFFECT OF ERYTHROPOIETIN ON GLASGOW COMA SCALE AND GLASGOW OUTCOME SCALE IN PATIENT WITH DIFFUSE AXONAL INJURY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2011;17(1):51-56. Available from: https://sid.ir/paper/593708/en

IEEE: Copy

SAEID ABRISHAMKAR, MOHAMMADREZA SAFAVI, and AZIM HONARMAND, “EFFECT OF ERYTHROPOIETIN ON GLASGOW COMA SCALE AND GLASGOW OUTCOME SCALE IN PATIENT WITH DIFFUSE AXONAL INJURY,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 17, no. 1, pp. 51–56, 2011, [Online]. Available: https://sid.ir/paper/593708/en

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