THE ACUTE EFFECTS OF TANACETUM PARTHENIUM ON MORPHINE WITHDRAWAL SIGNS IN ADULT MALE MICE

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ABDOLAHINIA A.; HEIDARIEH N.; KHOSHSOKHAN MOZAFFAR M.

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Journal: FINDINGS SCIENCE Year:2011 | Volume:7 | Issue:4 Page(s): 0-0

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Title

THE ACUTE EFFECTS OF TANACETUM PARTHENIUM ON MORPHINE WITHDRAWAL SIGNS IN ADULT MALE MICE

Author(s)

ABDOLAHINIA A. | HEIDARIEH N. | KHOSHSOKHAN MOZAFFAR M. | Issue Writer Certificate

Keywords

MORPHINE

NALOXONE

TANACETUM

MICE

Abstract

At present herb are considerably used to decrease symptoms of drug withdrawal syndrome and facilitate the withdrawal process. Since TANACETUM parthenium has anti-pain effects, the goal of this research is studying acute effects of hydroacoholic extract of TANACETUM on MORPHINE withdrawal signs in the adult male MICE.In this research adult male MICE NMRI (n=40 and 30gr), with weight limitation 30±2 gr, were divided into two original group; witness (saline) and MORPHINE. The MORPHINE group has 4 sub- groups their received different doses of TANACETUM and its solvent. The MORPHINE group in chronic method, during three days and each day 3 times with 6 hours intervals received doses of 10, 20 and 40 mg/kg respectively and at the fourth day it received 40 mg/kg MORPHINE one time as subcutaneous (S.C). The witness group also received only Saline with the same size during received the time. In all groups to infuse withdrawal syndrome, 3 hours after the last MORPHINE injection, a dose of NALOXONE 5 mg/kg was injected into introperitoneal (i.p).Three sub groups of MORPHINE 30 minutes before NALOXONE injection, the hydroacoholic extract of TANACETUM (code taken by herbarium of university) with doses of 10, 25 and 50 mg/kg was injected intraperitoneally. The control –group received solvent (saline).In all groups after NALOXONE injection, it was studied the MORPHINE withdrawal signs, including jumping, standing on two feet, climbing along a wall and putting lose weight for half hour.After recording all data, statistical analysis based on comparison of averages and one-way ANOVA test were implemented as well as Tukey test.Results showed in rats receiving hydroalchoholic extract of TANACETUM the MORPHINE withdrawal signs were significantly decreased.This is probably due to the opioid- like effects of hydroalchoholic extract of TANACETUM.

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APA: Copy

ABDOLAHINIA, A., HEIDARIEH, N., & KHOSHSOKHAN MOZAFFAR, M.. (2011). THE ACUTE EFFECTS OF TANACETUM PARTHENIUM ON MORPHINE WITHDRAWAL SIGNS IN ADULT MALE MICE. FINDINGS SCIENCE, 7(4), 0-0. SID. https://sid.ir/paper/594959/en

Vancouver: Copy

ABDOLAHINIA A., HEIDARIEH N., KHOSHSOKHAN MOZAFFAR M.. THE ACUTE EFFECTS OF TANACETUM PARTHENIUM ON MORPHINE WITHDRAWAL SIGNS IN ADULT MALE MICE. FINDINGS SCIENCE[Internet]. 2011;7(4):0-0. Available from: https://sid.ir/paper/594959/en

IEEE: Copy

A. ABDOLAHINIA, N. HEIDARIEH, and M. KHOSHSOKHAN MOZAFFAR, “THE ACUTE EFFECTS OF TANACETUM PARTHENIUM ON MORPHINE WITHDRAWAL SIGNS IN ADULT MALE MICE,” FINDINGS SCIENCE, vol. 7, no. 4, pp. 0–0, 2011, [Online]. Available: https://sid.ir/paper/594959/en

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