PREVENTION AND INHIBITION OF TC-1 CELL GROWTH IN TUMOR BEARING MICE BY HPV16 E7 PROTEIN IN FUSION WITH SHIGA TOXIN B-SUBUNIT FROM SHIGELLA DYSENTERIAE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SADRAEIAN MOHAMMAD; KHOSHNOOD MANSOORKHANI MOHAMMAD JAVAD; MOHKAM MILAD; RASOUL AMINI SARA; HESARAKI MAHDI; GHASEMI YOUNES

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2013 | Volume:15 | Issue:2 (58) Page(s): 176-181

Download Full-Text

View:

377

Download:

247

Cites:

Information Journal Paper

Title

PREVENTION AND INHIBITION OF TC-1 CELL GROWTH IN TUMOR BEARING MICE BY HPV16 E7 PROTEIN IN FUSION WITH SHIGA TOXIN B-SUBUNIT FROM SHIGELLA DYSENTERIAE

Author(s)

Keywords

PROTEIN VACCINE

E7-STXB

IMMUNIZATION

TUMOR GROWTH

CERVICAL CANCER

Abstract

Objective: For immunotherapy of human papillomavirus (HPV) -16-associated CERVICAL CANCERs the E7 protein is considered a prime candidate. However it is a poor inducer of cytotoxic T-cell response, when being used as a singular antigen in protein vaccination. Hence, in this study we focused on the utilization of a vaccine delivery system for prevention or treatment of CERVICAL CANCER.Materials and Methods: In this experimental study, we designed and evaluated a novel fusion protein comprising HPV16 E7 antigen fused to Shiga toxin B-subunit (STxB) as both an antigen vector and an adjuvant. Then we designed two preventive and therapeutic tumor models to investigate the prevention and inhibition of TC-1 cell growth in female C57BL/6 mice, respectively. In each model, mice were immunized with the recombinant protein of E7-STXB or E7 without any adjuvant.Results: We demonstrated that prophylactic IMMUNIZATION of E7-STXB protected mice against TC-1 cells. Also in the therapeutic model, E7-STXB inhibited TC-1 TUMOR GROWTH inlungs. The results were significant when compared with the IMMUNIZATION of E7 singularly.Conclusion: We concluded that IMMUNIZATION with the E7-STXB protein without any adjuvant could generate anti-tumor effect in mice challenged with TC-1 cells. This research verifies the clinical applications and the future prospects of developing HPV16 E7 therapeutic vaccines fused to immunoadjuvants.

Cites

No record.

References

Cite

APA: Copy

SADRAEIAN, MOHAMMAD, KHOSHNOOD MANSOORKHANI, MOHAMMAD JAVAD, MOHKAM, MILAD, RASOUL AMINI, SARA, HESARAKI, MAHDI, & GHASEMI, YOUNES. (2013). PREVENTION AND INHIBITION OF TC-1 CELL GROWTH IN TUMOR BEARING MICE BY HPV16 E7 PROTEIN IN FUSION WITH SHIGA TOXIN B-SUBUNIT FROM SHIGELLA DYSENTERIAE. CELL JOURNAL (YAKHTEH), 15(2 (58)), 176-181. SID. https://sid.ir/paper/596458/en

Vancouver: Copy

SADRAEIAN MOHAMMAD, KHOSHNOOD MANSOORKHANI MOHAMMAD JAVAD, MOHKAM MILAD, RASOUL AMINI SARA, HESARAKI MAHDI, GHASEMI YOUNES. PREVENTION AND INHIBITION OF TC-1 CELL GROWTH IN TUMOR BEARING MICE BY HPV16 E7 PROTEIN IN FUSION WITH SHIGA TOXIN B-SUBUNIT FROM SHIGELLA DYSENTERIAE. CELL JOURNAL (YAKHTEH)[Internet]. 2013;15(2 (58)):176-181. Available from: https://sid.ir/paper/596458/en

IEEE: Copy

MOHAMMAD SADRAEIAN, MOHAMMAD JAVAD KHOSHNOOD MANSOORKHANI, MILAD MOHKAM, SARA RASOUL AMINI, MAHDI HESARAKI, and YOUNES GHASEMI, “PREVENTION AND INHIBITION OF TC-1 CELL GROWTH IN TUMOR BEARING MICE BY HPV16 E7 PROTEIN IN FUSION WITH SHIGA TOXIN B-SUBUNIT FROM SHIGELLA DYSENTERIAE,” CELL JOURNAL (YAKHTEH), vol. 15, no. 2 (58), pp. 176–181, 2013, [Online]. Available: https://sid.ir/paper/596458/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops