PREPARATION AND QUALITY CONTROL OF 153SM- [TRIS (1, 10-PHENANTHROLINE) SAMARIUM (III)] COMPLEX AS A THERAPEUTIC COMPOUND

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HAKIMI AMIR; JALILIAN AMIR REZA; SHIRVANI ARANI SIMINDOKHT; NASERI ZOHRE; BAHRAMI SAMANI ALI; GHANNADI MARAGHEH MOHAMMAD; ARBABI AZIM

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2010 | Volume:18 | Issue:SUPPLEMENT 1 Page(s): 111-111

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Title

PREPARATION AND QUALITY CONTROL OF 153SM- [TRIS (1, 10-PHENANTHROLINE) SAMARIUM (III)] COMPLEX AS A THERAPEUTIC COMPOUND

Author(s)

Keywords

SAMARIUM-153

10-PHENANTHROLINE

RADIOLABELING

QUALITY CONTROL

Abstract

Introduction: In view of development of targeting therapeutic compounds for malignancies, and interesting in vitro anti-tumor activities of lanthanide phenanthroline complexes, the 153Sm- [tris (1, 10-PHENANTHROLINE) Samarium (III)] complex (153Sm-PL3) was prepared.Methods: Sm-153 chloride was obtained by thermal neutron flux (4 × 1013 n.cm-2.s-1) of enriched 152Sm2O3 sample, dissolved in acidic media. The labeling was performed in ethanol in 24h, controlled by ITLC (1.0mM DTPA, pH.5, as mobile phase). The partition coefficient for the labeled compound was determined.Results: A radiochemical yield of more than 95% was obtained. Radiochemical purity of 96% was obtained using ITLC with specific activity of about 27.75 GBq/mg. The radio-labeled complex was stable in aqueous solution at least 24 hours and no significant amount of free 153Sm was released from the complex. The partition coefficient for the labeled compound was determined (log P.3.4). The complex was stable in final formulation for 66h. The biological evaluation of the compound is under investigation.Conclusion: The radiolabeled compound used in this study is a very inexpensive and useful agent for use as a therapeutic compound.

Cites

DETERMINATION OF HUMAN ABSORBED DOSE FROM [153SM]-SAMARIUM MALTOLATE BASED ON DISTRIBUTION DATA IN RATS

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APA: Copy

HAKIMI, AMIR, JALILIAN, AMIR REZA, SHIRVANI ARANI, SIMINDOKHT, NASERI, ZOHRE, BAHRAMI SAMANI, ALI, GHANNADI MARAGHEH, MOHAMMAD, & ARBABI, AZIM. (2010). PREPARATION AND QUALITY CONTROL OF ¹⁵³SM- [TRIS (1, 10-PHENANTHROLINE) SAMARIUM (III)] COMPLEX AS A THERAPEUTIC COMPOUND. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 18(SUPPLEMENT 1), 111-111. SID. https://sid.ir/paper/599065/en

Vancouver: Copy

HAKIMI AMIR, JALILIAN AMIR REZA, SHIRVANI ARANI SIMINDOKHT, NASERI ZOHRE, BAHRAMI SAMANI ALI, GHANNADI MARAGHEH MOHAMMAD, ARBABI AZIM. PREPARATION AND QUALITY CONTROL OF ¹⁵³SM- [TRIS (1, 10-PHENANTHROLINE) SAMARIUM (III)] COMPLEX AS A THERAPEUTIC COMPOUND. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2010;18(SUPPLEMENT 1):111-111. Available from: https://sid.ir/paper/599065/en

IEEE: Copy

AMIR HAKIMI, AMIR REZA JALILIAN, SIMINDOKHT SHIRVANI ARANI, ZOHRE NASERI, ALI BAHRAMI SAMANI, MOHAMMAD GHANNADI MARAGHEH, and AZIM ARBABI, “PREPARATION AND QUALITY CONTROL OF ¹⁵³SM- [TRIS (1, 10-PHENANTHROLINE) SAMARIUM (III)] COMPLEX AS A THERAPEUTIC COMPOUND,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 18, no. SUPPLEMENT 1, pp. 111–111, 2010, [Online]. Available: https://sid.ir/paper/599065/en

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