ASSOCIATION BETWEEN EXOTOXIN A (EXO-A) GENE AND ANTIBIOTIC RESISTANCE PATTERN WITH BIOFILM FORMATION IN PSEUDOMONAS AERUGINOSA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

IMANI FOOLADI A.A.; HOSAINZADEH M.; MOUSAVI S.F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Ardabil University of Medical Sciences Year:2011 | Volume:11 | Issue:1 (39) Page(s): 7-13

Download Full-Text

Persian Verion

View:

1,716

Download:

Cites:

Information Journal Paper

Title

ASSOCIATION BETWEEN EXOTOXIN A (EXO-A) GENE AND ANTIBIOTIC RESISTANCE PATTERN WITH BIOFILM FORMATION IN PSEUDOMONAS AERUGINOSA

Author(s)

IMANI FOOLADI A.A. | HOSAINZADEH M. | MOUSAVI S.F. | Issue Writer Certificate

Keywords

PSEUDOMONAS AERUGINOSAQ2

EXOTOXIN AQ2

ANTIBIOTIC RESISTANCE PATTERNQ2

BIOFILMQ2

Abstract

Background & Objectives: PSEUDOMONAS AERUGINOSA is a Gram-negative and aerobic bacterium. EXOTOXIN A is one of the important toxins produced by the bacterium and it is the main cause of mortality. About 90% of P. aeruginosa strains produce this toxin. BIOFILM is a functional consortium of microorganisms attached to the body surfaces and bacteria are embedded in extracellular polymeric substances produced by the microorganisms. This bacterium is nontoxic in the planktonic form, but as a BIOFILM is highly toxic. In this study, we examined the association between the presence of exo-A gene and ANTIBIOTIC RESISTANCE PATTERNs with BIOFILM formation in PSEUDOMONAS AERUGINOSA strains.Methods: In this study 110 strains of PSEUDOMONAS AERUGINOSA isolated from various infections with defined ANTIBIOTIC RESISTANCE PATTERNs were used. The PCR method was used to detect the presence or absence of EXOTOXIN A gene (exo-A). Ability of BIOFILM formation was evaluated by spectrophotometry. Association between exo-A gene and ANTIBIOTIC RESISTANCE PATTERNs with BIOFILMs formation was analyzed statistically by Fishers and Chi-square tests.Results: exo-A gene was detected in 93 strains (84.5%). Sixty two strains were multidrug resistant and they produced broad spectrum beta-Iactamase enzyme. Results showed that, exo-A positive strains had significantly higher ability to BIOFILM formation in comparison with exo-A negative strains (p<0.05). Also the BIOFILM formation was significantly higher in multidrug resistant and ESBL producing strains (p<0.05).Conclusion: The results of this study indicate that there is a significant association between exo-A gene as well as ANTIBIOTIC RESISTANCE PATTERN and ESBI producing with BIOFILM formation in PSEUDOMONAS AERUGINOSA. Because of importance of BIOFILMs in the pathogenesis of this bacterium, our study could open a new window for investigation of the molecular processes involved in the formation ofbiofilms.

Cites

MOLECULAR STUDY OF THE PREVALENCE OF EXOTOXIN A AND ALGINATE GENE IN PSEUDOMONAS AERUGINOSA ISOLATES IN BURN WOUNDS SAMPLES

References

No record.

Cite

APA: Copy

IMANI FOOLADI, A.A., HOSAINZADEH, M., & MOUSAVI, S.F.. (2011). ASSOCIATION BETWEEN EXOTOXIN A (EXO-A) GENE AND ANTIBIOTIC RESISTANCE PATTERN WITH BIOFILM FORMATION IN PSEUDOMONAS AERUGINOSA. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 11(1 (39)), 7-13. SID. https://sid.ir/paper/59964/en

Vancouver: Copy

IMANI FOOLADI A.A., HOSAINZADEH M., MOUSAVI S.F.. ASSOCIATION BETWEEN EXOTOXIN A (EXO-A) GENE AND ANTIBIOTIC RESISTANCE PATTERN WITH BIOFILM FORMATION IN PSEUDOMONAS AERUGINOSA. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2011;11(1 (39)):7-13. Available from: https://sid.ir/paper/59964/en

IEEE: Copy

A.A. IMANI FOOLADI, M. HOSAINZADEH, and S.F. MOUSAVI, “ASSOCIATION BETWEEN EXOTOXIN A (EXO-A) GENE AND ANTIBIOTIC RESISTANCE PATTERN WITH BIOFILM FORMATION IN PSEUDOMONAS AERUGINOSA,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 11, no. 1 (39), pp. 7–13, 2011, [Online]. Available: https://sid.ir/paper/59964/en

Related Journal Papers