THE ASSOCIATION BETWEEN BRCA1 EXPRESSION AND BREAST CANCER TUMOROGENESIS

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DAVARNIA B.; MEHDIPOUR P.; AREI M.; HOSSEINI ASL S.S.

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Journal: JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS) Year:2012 | Volume:12 | Issue:2 (44) Page(s): 132-139

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Information Journal Paper

Title

THE ASSOCIATION BETWEEN BRCA1 EXPRESSION AND BREAST CANCER TUMOROGENESIS

Author(s)

DAVARNIA B. | MEHDIPOUR P. | AREI M. | HOSSEINI ASL S.S. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

BRCA1Q3

EXPRESSION LEVELQ2

Abstract

Background & Objectives: BREAST CANCER is among the most frequent disorders among the world. BRCA1 gene was known as a tumor suppressor gene which its loss could be resulted in various destructions in genome. Therefore, changes occurred in its EXPRESSION LEVEL could lead to increasing the effects of oncogene activity on breast cells.Methods: RT-PCR and Q-RT-PCR were used for detecting BRCA1 expression status among 27 primary affected BREAST CANCER patients. The association between its expression status and histopathologic data had been evaluated by statistical assays.Results: Eighty-five percent of patients showed BRCA1 expression and this expression as well as its quantity had significant associations with tumor grade. It was found that tumors with low levels of BRCA1 expression tend to have higher grades.Conclusion: BRCA1 has an important role in suppressing breast tumorogenesis.Corresponding to some of the previous reports, our findings revealed the role of decreasing in BRCA1 EXPRESSION LEVEL as one of the factors which allows tumors to progress.

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APA: Copy

DAVARNIA, B., MEHDIPOUR, P., AREI, M., & HOSSEINI ASL, S.S.. (2012). THE ASSOCIATION BETWEEN BRCA1 EXPRESSION AND BREAST CANCER TUMOROGENESIS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 12(2 (44)), 132-139. SID. https://sid.ir/paper/60062/en

Vancouver: Copy

DAVARNIA B., MEHDIPOUR P., AREI M., HOSSEINI ASL S.S.. THE ASSOCIATION BETWEEN BRCA1 EXPRESSION AND BREAST CANCER TUMOROGENESIS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2012;12(2 (44)):132-139. Available from: https://sid.ir/paper/60062/en

IEEE: Copy

B. DAVARNIA, P. MEHDIPOUR, M. AREI, and S.S. HOSSEINI ASL, “THE ASSOCIATION BETWEEN BRCA1 EXPRESSION AND BREAST CANCER TUMOROGENESIS,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 12, no. 2 (44), pp. 132–139, 2012, [Online]. Available: https://sid.ir/paper/60062/en

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