THE EFFECT OF ESTROGEN ON VISCERAL FAT, SERUM OMENTIN-1 AND INSULIN RESISTANCE IN OVARIECTOMIZED RATS

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BABAEI P.; DAMIRCHI A.; POURRAHIM GHOUROUGHCHI A.

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Journal: JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS) Year:2016 | Volume:16 | Issue:2 Page(s): 189-199

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Title

THE EFFECT OF ESTROGEN ON VISCERAL FAT, SERUM OMENTIN-1 AND INSULIN RESISTANCE IN OVARIECTOMIZED RATS

Author(s)

BABAEI P. | DAMIRCHI A. | POURRAHIM GHOUROUGHCHI A. | Issue Writer Certificate

Keywords

ESTROGENQ2

VISCERAL FATQ2

OMENTINE-1Q1

INSULIN RESISTANCEQ1

OVARIECTOMIZED RATSQ2

Abstract

Background & objectives: ESTROGEN reduction after the menopause is associated with visceral adipose tissue accumulation and INSULIN RESISTANCE. Serum omentin-1 level is also decreased by abdominal obesity and INSULIN RESISTANCE. This study investigated the effect of ESTROGEN on VISCERAL FAT, omentin-1 and INSULIN RESISTANCE in ovariectomized (OVX) rats.Methods: Thirty 13-week-old female Wistar rats weighing180±5 gr were randomly matched on their body weight and divided into OVX (n=20) and sham-operated (SHAM; n=10) groups. OVX rats were subdivided into ESTROGEN replacement therapy (Ovx+Est; n=10), and control (Ovx+sesame Oil; n=10) groups. The ESTROGEN replacement therapy received 17bestradiol (30μg/kg bw; in 0.2 ml sesame oil) three days a week, for eight weeks. Ovx+Oil received the same sesame oil subcutaneously as vehicle. All intra-abdominal fat depots were dissected out and weighed immediately. Omentin-1 concentration was measured by rat omentin ELISA kit and HOMA-IR was used to estimate the INSULIN RESISTANCE. Obtained data were analyzed by ANOVA and post hoc Tukey test.Results: VISCERAL FAT was decreased by 12.84% in Ovx+Est compared to Ovx+Oil group; but it wasn ́t significant. Whereas, body weight was significantly decreased by 7.87 % in Ovx+Est compared to Ovx+Oil; and it was significantly increased by 12.5% in Ovx+Oil compared to SHAM group. Omentin-1 level was significantly increased by 41% in Ovx+Est compared to Ovx+Oil group; whereas it was significantly decreased by 13.9% in Ovx+Oil compared to SHAM group. The levels of glucose, insulin and HOMA-IR were significantly decreased to 51.16%, 24.23% and 61.52%, respectively, in Ovx+Est group compared to the rats in Ovx+Oil group (p=0.0001).Conclusion: 8-week ESTROGEN reduces body weight and improves INSULIN RESISTANCE probably via increase in omentin-1.

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APA: Copy

BABAEI, P., DAMIRCHI, A., & POURRAHIM GHOUROUGHCHI, A.. (2016). THE EFFECT OF ESTROGEN ON VISCERAL FAT, SERUM OMENTIN-1 AND INSULIN RESISTANCE IN OVARIECTOMIZED RATS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 16(2), 189-199. SID. https://sid.ir/paper/60104/en

Vancouver: Copy

BABAEI P., DAMIRCHI A., POURRAHIM GHOUROUGHCHI A.. THE EFFECT OF ESTROGEN ON VISCERAL FAT, SERUM OMENTIN-1 AND INSULIN RESISTANCE IN OVARIECTOMIZED RATS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2016;16(2):189-199. Available from: https://sid.ir/paper/60104/en

IEEE: Copy

P. BABAEI, A. DAMIRCHI, and A. POURRAHIM GHOUROUGHCHI, “THE EFFECT OF ESTROGEN ON VISCERAL FAT, SERUM OMENTIN-1 AND INSULIN RESISTANCE IN OVARIECTOMIZED RATS,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 16, no. 2, pp. 189–199, 2016, [Online]. Available: https://sid.ir/paper/60104/en

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