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Information Journal Paper

Title

EXPRESSION AND PROGNOSTIC SIGNIFICANCE OF BCL-2 AND BAX IN THE PROGRESSION AND CLINICAL OUTCOME OF TRANSITIONAL BLADDER CELL CARCINOMA

Pages

  356-363

Abstract

 Objective: To evaluate the mRNA expression ratio of BCL-2/Bax both in normal and tumoral BLADDER tissues of patients with transitional cell carcinoma (TCC) of BLADDER and investigate potential correlation between this expression ratio and CLINICAL OUTCOME.Materials and Methods: In this experimental study, we used real time-PCR to investigate the expression of BCL-2 and BAX both in normal and tumoral BLADDER tissues. The BCL-2/Bax expression ratio was determined in tumoral BLADDER tissues of patients with transitional cell carcinoma of the BLADDER (n=40) and correlation between expression ratios and the emergence of early relapses in a follow-up of 14-30 months was examined.Results: Relapse-free time in 14.31 patients (45.16%) with BCL-2/Bax>1 was shorter than 9 months (range of 2-9 months) with 5.7 months average median while 17.31 patients (54.84%) with BCL-2/Bax<1 are currently relapse-free (14-30 months). BCL-2 and BAX expression levels were not solely correlated with CLINICAL OUTCOME and progression of carcinogenesis.Conclusion: The mRNA expression ratio of BCL-2/Bax in tumoral BLADDER tissues may serve as a significant prognostic indicator in predicting the CLINICAL OUTCOME in low grade non-invasive BLADDER cancer.

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    APA: Copy

    GOLESTANI EIMANI, BAHRAM, SANATI, MOHAMMAD HOSSEIN, HOUSHMAND, MASOUD, ATAIE, MITRA, AKBARIAN, FATEMEH, & SHAKHSSALIM, NASER. (2014). EXPRESSION AND PROGNOSTIC SIGNIFICANCE OF BCL-2 AND BAX IN THE PROGRESSION AND CLINICAL OUTCOME OF TRANSITIONAL BLADDER CELL CARCINOMA. CELL JOURNAL (YAKHTEH), 15(4 (60)), 356-363. SID. https://sid.ir/paper/601937/en

    Vancouver: Copy

    GOLESTANI EIMANI BAHRAM, SANATI MOHAMMAD HOSSEIN, HOUSHMAND MASOUD, ATAIE MITRA, AKBARIAN FATEMEH, SHAKHSSALIM NASER. EXPRESSION AND PROGNOSTIC SIGNIFICANCE OF BCL-2 AND BAX IN THE PROGRESSION AND CLINICAL OUTCOME OF TRANSITIONAL BLADDER CELL CARCINOMA. CELL JOURNAL (YAKHTEH)[Internet]. 2014;15(4 (60)):356-363. Available from: https://sid.ir/paper/601937/en

    IEEE: Copy

    BAHRAM GOLESTANI EIMANI, MOHAMMAD HOSSEIN SANATI, MASOUD HOUSHMAND, MITRA ATAIE, FATEMEH AKBARIAN, and NASER SHAKHSSALIM, “EXPRESSION AND PROGNOSTIC SIGNIFICANCE OF BCL-2 AND BAX IN THE PROGRESSION AND CLINICAL OUTCOME OF TRANSITIONAL BLADDER CELL CARCINOMA,” CELL JOURNAL (YAKHTEH), vol. 15, no. 4 (60), pp. 356–363, 2014, [Online]. Available: https://sid.ir/paper/601937/en

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