MOLECULAR EPIDEMIOLOGY OF CARBAPENEM RESISTANCE IN ACINETOBACTER BAUMANNII ISOLATES IN SHAHID MOHAMMADI HOSPITAL, BANDAR ABBAS, IRAN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAJAR PEERAYEH S.; KARMOSTAJI A.; ANSARI M.; JAVADPOUR D.; DAVOODIAN P.; MORADI N.; VAHDANI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Hormozgan Medical Journal Year:2015 | Volume:19 | Issue:1 Page(s): 19-27

Download Full-Text

Persian Verion

View:

759

Download:

162

Cites:

Information Journal Paper

Title

MOLECULAR EPIDEMIOLOGY OF CARBAPENEM RESISTANCE IN ACINETOBACTER BAUMANNII ISOLATES IN SHAHID MOHAMMADI HOSPITAL, BANDAR ABBAS, IRAN

Author(s)

Keywords

A CINETOBACTER BAUMANNIIQ2

CARBAPENEMASEQ2

OXAQ2

58 BETA-LACTMASEQ2

Abstract

Introduction: Acinetobacter baumannii is a major cause of nosocomial infections which affect mainly disabled patients in intensive care units. The bacteria may acquire resistance to antibiotics and hence can seriously endanger antibiotic therapy. The most important problem facing treatment of A. baumannii is increasing reports of resistance to a wide range of antibiotics, including carbapenems, as the treatment of choice for this bacterial infection. OXAcillinase-type CARBAPENEMASEs belonging to Class D beta-lactamases (OXAtype) are among the main mechanisms of reasons for resistance to carbapenems. The present study aimed to evaluate the patterns of antibiotic resistance and the prevalence of CARBAPENEMASE genes of OXAcillinases in clinical isolates of A. baumannii in a hospital in Bandar Abbas, Iran.Methods: A total of 69 isolates of Acinetobacter were collected within two years from different samples of patients’ bodies in the Shahid Mohammadi Hospital of Bandar Abbas. The isolates genus was identified using biochemical methods and A. baumannii species using PCR. Antibiotic resistance to imipenem and meropenem was identified through disk diffusion method. OXA-type carbapenem resistance genes were identified by multiplex PCR. The data were statistically analyzed through the chi-square test using SPSS 17, and the graphs were plotted using Excel.Results: Out of 69 Acinetobacter isolates, 57 (82.6%) had blaOXA-51 gene and were identified as A. baumannii. Antibiogram showed a significant resistance to beta-lactams and other antibiotics studied. The resistance percentage of the isolates to imipenem and meropenem antibiotics were 29.8% and 70.2%, respectively. Although all isolates were susceptible to colistin and polymyxin B, 78.9% of isolates had blaoxa-23, 8.8% blaOXA-24, and 1.7% blaOXA-58 genes.Conclusion: This study showed that beta-lactamase OXA-23 gene is the common identified known CARBAPENEMASE among carbapenem-resistant A. baumannii in Bandar Abbas Hospital. Evaluation of antibiotic-resistant genes in A. baumannii is necessary to further control dissemination of antibiotic resistance genes.

Cites

No record.

References

No record.

Cite

APA: Copy

NAJAR PEERAYEH, S., KARMOSTAJI, A., ANSARI, M., JAVADPOUR, D., DAVOODIAN, P., MORADI, N., & VAHDANI, M.. (2015). MOLECULAR EPIDEMIOLOGY OF CARBAPENEM RESISTANCE IN ACINETOBACTER BAUMANNII ISOLATES IN SHAHID MOHAMMADI HOSPITAL, BANDAR ABBAS, IRAN. HORMOZGAN MEDICAL JOURNAL, 19(1), 19-27. SID. https://sid.ir/paper/60377/en

Vancouver: Copy

NAJAR PEERAYEH S., KARMOSTAJI A., ANSARI M., JAVADPOUR D., DAVOODIAN P., MORADI N., VAHDANI M.. MOLECULAR EPIDEMIOLOGY OF CARBAPENEM RESISTANCE IN ACINETOBACTER BAUMANNII ISOLATES IN SHAHID MOHAMMADI HOSPITAL, BANDAR ABBAS, IRAN. HORMOZGAN MEDICAL JOURNAL[Internet]. 2015;19(1):19-27. Available from: https://sid.ir/paper/60377/en

IEEE: Copy

S. NAJAR PEERAYEH, A. KARMOSTAJI, M. ANSARI, D. JAVADPOUR, P. DAVOODIAN, N. MORADI, and M. VAHDANI, “MOLECULAR EPIDEMIOLOGY OF CARBAPENEM RESISTANCE IN ACINETOBACTER BAUMANNII ISOLATES IN SHAHID MOHAMMADI HOSPITAL, BANDAR ABBAS, IRAN,” HORMOZGAN MEDICAL JOURNAL, vol. 19, no. 1, pp. 19–27, 2015, [Online]. Available: https://sid.ir/paper/60377/en

Related Journal Papers