IL-7R α POLYMORPHISMS IN 60 IRANIAN MULTIPLE SCLEROSIS PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AHMADZADEH RAJI MOJGAN; KHOSRAVI ALIREZA; SANATI MOHAMMAD HOSSEIN; NABAVI SEYED MASSOOD; HAJIHOSEINI REZA; EBRAHIMI AHMAD; SABOUR MOHAMMAD HOSSEIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Current Journal of Neurology Year:2012 | Volume:11 | Issue:1 Page(s): 6-11

Download Full-Text

View:

228

Download:

106

Cites:

Information Journal Paper

Title

IL-7R α POLYMORPHISMS IN 60 IRANIAN MULTIPLE SCLEROSIS PATIENTS

Author(s)

Keywords

IL-7R α

POLYMORPHISM

SNPS

SSCP

SEQUENCING

MULTIPLE SCLEROSIS

Abstract

Background: MULTIPLE SCLEROSIS (MS), a chronic inflammatory demyelinating disorder with neurodegenerative aspects, is more common among young adults, particularly women.Methods: This molecular study was designed to investigate the IL-7R α chain gene in Iranian MS patients. We studied 60 MS patients, diagnosed based on 2005 R-McDonald criteria and 60 apparently healthy individuals as the control group.DNA was extracted from whole blood cells using MBST/IRAN Extraction kit and all samples were screened for possible sequence variation in three regions including promoter, exon 2 and exon 4 with single strand conformation POLYMORPHISM (SSCP).Results: The alterations were confirmed with direct SEQUENCING by ABI 3730XL. Although no mutation was detected in the studied regions, eight single nucleotide POLYMORPHISMs (SNPs) consisting of rs71617734 in promoter; rs35967524, rs11567704, rs1494558, rs11567705 and rs969128 in exon 2 as well as rs1494555 and rs2228141 in exon 4 were observed. The rs1494558 in exon 2 and rs1494555 in exon 4 were missense variations. Our results also showed the substitution of isoleucine with threonine in rs1494558 (P.I66T) with this accession number, FR863587 submitted in EMBL bank.The study of exon4 areas revealed two SNPS and two sequence variations, where [p.V138I] Valine substituted with isoleucine (FR863588), as well as a silent nucleotide substitution [P. H165H] in the absence of amino acid alteration. The analysis of the SNP genotype in the controls and the patients, using χ2 showed no significant association with MULTIPLE SCLEROSIS in this group.Conclusion: Our study demonstrated the effects of some SNPS on the IL-7R α protein in MS. Further studies are required to reveal the effects of these SNPS on the IL-7R α protein in MULTIPLE SCLEROSIS.

Cites

No record.

References

No record.

Cite

APA: Copy

AHMADZADEH RAJI, MOJGAN, KHOSRAVI, ALIREZA, SANATI, MOHAMMAD HOSSEIN, NABAVI, SEYED MASSOOD, HAJIHOSEINI, REZA, EBRAHIMI, AHMAD, & SABOUR, MOHAMMAD HOSSEIN. (2012). IL-7R α POLYMORPHISMS IN 60 IRANIAN MULTIPLE SCLEROSIS PATIENTS. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 11(1), 6-11. SID. https://sid.ir/paper/605647/en

Vancouver: Copy

AHMADZADEH RAJI MOJGAN, KHOSRAVI ALIREZA, SANATI MOHAMMAD HOSSEIN, NABAVI SEYED MASSOOD, HAJIHOSEINI REZA, EBRAHIMI AHMAD, SABOUR MOHAMMAD HOSSEIN. IL-7R α POLYMORPHISMS IN 60 IRANIAN MULTIPLE SCLEROSIS PATIENTS. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2012;11(1):6-11. Available from: https://sid.ir/paper/605647/en

IEEE: Copy

MOJGAN AHMADZADEH RAJI, ALIREZA KHOSRAVI, MOHAMMAD HOSSEIN SANATI, SEYED MASSOOD NABAVI, REZA HAJIHOSEINI, AHMAD EBRAHIMI, and MOHAMMAD HOSSEIN SABOUR, “IL-7R α POLYMORPHISMS IN 60 IRANIAN MULTIPLE SCLEROSIS PATIENTS,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 11, no. 1, pp. 6–11, 2012, [Online]. Available: https://sid.ir/paper/605647/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops