REVERSIBLE THERAPY-RELATED DYSPLASTIC HEMATOPOIESIS FOLLOWING BETA INTERFERON THERAPY IN MULTIPLE SCLEROSIS PATIENTS: REPORT OF 2 CASES

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NABAVI SEYED MASSOOD; HAMZEHLOO ALI; SHAMS JALALEDIN; MORSALI DAMINEH

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Journal: Current Journal of Neurology Year:2011 | Volume:10 | Issue:1-2 Page(s): 32-34

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Title

REVERSIBLE THERAPY-RELATED DYSPLASTIC HEMATOPOIESIS FOLLOWING BETA INTERFERON THERAPY IN MULTIPLE SCLEROSIS PATIENTS: REPORT OF 2 CASES

Author(s)

NABAVI SEYED MASSOOD | HAMZEHLOO ALI | SHAMS JALALEDIN | MORSALI DAMINEH | Issue Writer Certificate

Keywords

DYSPLASTIC HEMATOPOIESIS

BETA INTERFERON THERAPY

MULTIPLE SCLEROSIS

Abstract

Background: Interferon beta-la and -1b have been increasingly used for the treatment of MULTIPLE SCLEROSIS (MS). The most frequent systemic adverse effects are flulike symptoms. Laboratory abnormalities include asymptomatic leukopenia and elevated hepatic transaminases. Myelodysplastic Syndrome (MDS) refers to a spectrum of hematological disorders which can occur in different situations. Several hematological abnormalities have been reported following interferon therapy.Methods: We report two cases of secondary MDS after long term interferon therapy by using the laboratory data and bone marrow results.Conclusion: Both of our cases were reversible; although treatment with IFNb-1a and-1b is safe and well tolerated in the majority of population, we should be careful about this premalignant hematological disorder.

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APA: Copy

NABAVI, SEYED MASSOOD, HAMZEHLOO, ALI, SHAMS, JALALEDIN, & MORSALI, DAMINEH. (2011). REVERSIBLE THERAPY-RELATED DYSPLASTIC HEMATOPOIESIS FOLLOWING BETA INTERFERON THERAPY IN MULTIPLE SCLEROSIS PATIENTS: REPORT OF 2 CASES. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 10(1-2), 32-34. SID. https://sid.ir/paper/605655/en

Vancouver: Copy

NABAVI SEYED MASSOOD, HAMZEHLOO ALI, SHAMS JALALEDIN, MORSALI DAMINEH. REVERSIBLE THERAPY-RELATED DYSPLASTIC HEMATOPOIESIS FOLLOWING BETA INTERFERON THERAPY IN MULTIPLE SCLEROSIS PATIENTS: REPORT OF 2 CASES. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2011;10(1-2):32-34. Available from: https://sid.ir/paper/605655/en

IEEE: Copy

SEYED MASSOOD NABAVI, ALI HAMZEHLOO, JALALEDIN SHAMS, and DAMINEH MORSALI, “REVERSIBLE THERAPY-RELATED DYSPLASTIC HEMATOPOIESIS FOLLOWING BETA INTERFERON THERAPY IN MULTIPLE SCLEROSIS PATIENTS: REPORT OF 2 CASES,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 10, no. 1-2, pp. 32–34, 2011, [Online]. Available: https://sid.ir/paper/605655/en

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