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Information Journal Paper

Title

COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE EFFICACY ALONG WITH GONADOTROPHINS IN CONTROLLED OVARIAN HYPERSTIMULATION FOR INTRAUTERINE INSEMINATION CYCLES

Pages

  138-142

Abstract

 Background: We performed this study to investigate and compare the effects of LETROZOLE and GONADOTROPHINs versus Clomiphene Citrate and GONADOTROPHINs in women undergoing superovulation for INTRAUTERINE INSEMINATION (IUI).Methods: We performed this prospective cohort study at Australian Concept and Fertility centre, Karachi Pakistan. Women younger than 40 years of age with patent fallopian tubes and INFERTILITY of more than 2 years in duration who were undergoing IUI and GONADOTROPHINs therapy were divided into two groups, one received LETROZOLE for 5 days and another received Clomiphene Citrate for 5 days.Results: All 500 IUI treatment cycles conducted from March 2008 to March 2010 were included. Patients co-treated with LETROZOLE required fewer GONADOTROPHINs administrations (median difference, 300IU (95% confidence interval (CI), 225−375 IU), developed more follicles larger than 14 mm (median difference, 1 follicle, 95% CI, 1−2 follicles), and had a thicker endometrium (median difference, 1 mm, 95% CI, 0.4–1.6mm). The PREGNANCY rate was not significantly different between two groups (11%vs.12.6%).Conclusion: The addition of LETROZOLE to GONADOTROPHINs decreases GONADOTROPHINs requirements and improves endometrial thickness, without a significant effect on PREGNANCY rates. An improved PREGNANCY rate has been observed in older age group, >35 years with LETROZOLE.

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    • Cite

    APA: Copy

    HAQNAWAZ, FAUZIA, VIRK, SAADIA, QADIR, TASLEEM, IMAM, SAADIA, & RIZVI, JAVED. (2013). COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE EFFICACY ALONG WITH GONADOTROPHINS IN CONTROLLED OVARIAN HYPERSTIMULATION FOR INTRAUTERINE INSEMINATION CYCLES. JOURNAL OF REPRODUCTION AND INFERTILITY, 14(3 (56)), 138-142. SID. https://sid.ir/paper/606892/en

    Vancouver: Copy

    HAQNAWAZ FAUZIA, VIRK SAADIA, QADIR TASLEEM, IMAM SAADIA, RIZVI JAVED. COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE EFFICACY ALONG WITH GONADOTROPHINS IN CONTROLLED OVARIAN HYPERSTIMULATION FOR INTRAUTERINE INSEMINATION CYCLES. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2013;14(3 (56)):138-142. Available from: https://sid.ir/paper/606892/en

    IEEE: Copy

    FAUZIA HAQNAWAZ, SAADIA VIRK, TASLEEM QADIR, SAADIA IMAM, and JAVED RIZVI, “COMPARISON OF LETROZOLE AND CLOMIPHENE CITRATE EFFICACY ALONG WITH GONADOTROPHINS IN CONTROLLED OVARIAN HYPERSTIMULATION FOR INTRAUTERINE INSEMINATION CYCLES,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 14, no. 3 (56), pp. 138–142, 2013, [Online]. Available: https://sid.ir/paper/606892/en

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