ERYTHROCYTE PYRUVATE KINASE DEFICIENCY AMONG ANEMIC INDIVIDUALS IN BANDAR ABBAS, IRAN

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YAVARIAN M.; FARSHID FAR GH.R.; PARAN F.

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Journal: Hormozgan Medical Journal Year:2006 | Volume:10 | Issue:1 Page(s): 1-6

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Title

ERYTHROCYTE PYRUVATE KINASE DEFICIENCY AMONG ANEMIC INDIVIDUALS IN BANDAR ABBAS, IRAN

Author(s)

YAVARIAN M. | FARSHID FAR GH.R. | PARAN F. | Issue Writer Certificate

Keywords

PYRUVATE KINASQ3

ANEMIAQ3

HEMOLYTICQ3

CONGENITALQ3

BANDAR ABBASQ3

Abstract

In addition to G6PD deficiency, human erythrocyte PYRUVATE KINASe (PK-R) deficiency is one of the most common causes of non-spherocytic HEMOLYTIC ANEMIA. Clinical severity of this disorder is not the same in homozygote form of this disease and ranges from mild to chronic and ANEMIA; so it has a wide variation. Severely effected individuals require blood transfusions or splenectomy.Methods: In this experimental study, a complete blood count (CBC) was performed on 2300 individuals aged 15-30 years from BANDAR ABBAS in Hormozgan province, to determine the possible HEMOLYTIC ANEMIA. From this cohort 800 non-related individuals who had hemoglobin levels below 11.5 g/dl were selected for further investigation and measured erythrocyte PK activity.Results: The enzyme activity levels expected in normal population had a range of 2.2-9.7 U/gmHb while in the anemic group; the range was 0.1-11.7 U/gmHb. In 123 cases (15%) among the anemic group, 20% to 40% of the normal enzyme activity was measured when compared with the values expected in heterogeneous individuals. Only three individuals (0.3%) in this group had below 20% of normal enzyme activity.Conclusion: The study revealed that the estimated gene frequency of PK deficiency in this area is about 36 in 1000 population and the observed carrier frequency is about 5%. If we can identify the couples who are at risk of PK deficiency, it may be possible to reduce the burden of chronic ANEMIA caused by PK deficiency.

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APA: Copy

YAVARIAN, M., FARSHID FAR, GH.R., & PARAN, F.. (2006). ERYTHROCYTE PYRUVATE KINASE DEFICIENCY AMONG ANEMIC INDIVIDUALS IN BANDAR ABBAS, IRAN. HORMOZGAN MEDICAL JOURNAL, 10(1), 1-6. SID. https://sid.ir/paper/60695/en

Vancouver: Copy

YAVARIAN M., FARSHID FAR GH.R., PARAN F.. ERYTHROCYTE PYRUVATE KINASE DEFICIENCY AMONG ANEMIC INDIVIDUALS IN BANDAR ABBAS, IRAN. HORMOZGAN MEDICAL JOURNAL[Internet]. 2006;10(1):1-6. Available from: https://sid.ir/paper/60695/en

IEEE: Copy

M. YAVARIAN, GH.R. FARSHID FAR, and F. PARAN, “ERYTHROCYTE PYRUVATE KINASE DEFICIENCY AMONG ANEMIC INDIVIDUALS IN BANDAR ABBAS, IRAN,” HORMOZGAN MEDICAL JOURNAL, vol. 10, no. 1, pp. 1–6, 2006, [Online]. Available: https://sid.ir/paper/60695/en

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