PROGNOSTIC MOLECULAR MARKERS IN HEPATOCELLULAR CARCINOMA (REVIEW ARTICLE)

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NOORI DALOII M.R.; ALIZADEH F.

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Journal: Hormozgan Medical Journal Year:2011 | Volume:15 | Issue:2 Page(s): 74-89

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Information Journal Paper

Title

PROGNOSTIC MOLECULAR MARKERS IN HEPATOCELLULAR CARCINOMA (REVIEW ARTICLE)

Author(s)

NOORI DALOII M.R. | ALIZADEH F. | Issue Writer Certificate

Keywords

HEPATOCELLULAR CARCINOMAQ2

GENEQ2

PROGNOSISQ3

Abstract

HEPATOCELLULAR CARCINOMA (HCC) is the 5th commonest malignancy worldwide and is the third most common cause of cancer-related death. The prevalence is different in the world. The ability to predict patients at higher risk of recurrence and with a poor PROGNOSIS would help to guide surgical and chemotherapeutic treatment according to individual risk.As understanding of hepatocarcinogenesis has increased, the myriad of GENEtic and molecular events that drive the hepatocarcinogenic disease process, including angiogenesis, invasion and metastasis, have been identified. With advances in understanding of tumor biology, interest in molecular biomarkers of carcinogenesis has grown, both in terms of their prognostic significance and also their potential as therapeutic targets. Several molecular markers with prognostic significance have been identified in HCC. Not only these molecules may allow accurate prediction of PROGNOSIS of patients with HCC and allow targeting of therapy, but they may also represent novel targets for therapeutic agents.The aim of this review was to examine the current knowledge regarding the prognostic role of the most important molecular biomarkers in HCC. In this article prognostic value of the following molecular markers is discussed: tumor suppressor GENEs; oncogenes; cell cycle regulators; apoptotic regulators; markers of angiogenesis; markers of invasion and metastasis; growth factors and receptors; telomerase; markers of genomic instability; aneuploidy and markers of microsatellite instability.

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APA: Copy

NOORI DALOII, M.R., & ALIZADEH, F.. (2011). PROGNOSTIC MOLECULAR MARKERS IN HEPATOCELLULAR CARCINOMA (REVIEW ARTICLE). HORMOZGAN MEDICAL JOURNAL, 15(2), 74-89. SID. https://sid.ir/paper/60720/en

Vancouver: Copy

NOORI DALOII M.R., ALIZADEH F.. PROGNOSTIC MOLECULAR MARKERS IN HEPATOCELLULAR CARCINOMA (REVIEW ARTICLE). HORMOZGAN MEDICAL JOURNAL[Internet]. 2011;15(2):74-89. Available from: https://sid.ir/paper/60720/en

IEEE: Copy

M.R. NOORI DALOII, and F. ALIZADEH, “PROGNOSTIC MOLECULAR MARKERS IN HEPATOCELLULAR CARCINOMA (REVIEW ARTICLE),” HORMOZGAN MEDICAL JOURNAL, vol. 15, no. 2, pp. 74–89, 2011, [Online]. Available: https://sid.ir/paper/60720/en

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