NANOSUSPENSIONS: A NEW APPROACH IN DRUG DELIVERY

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AGHAJANI M.; PASHAZADEH A.M.; AMANI A.; MOSTAFAVI S.H.

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Journal Paper

Paper Information

Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2013 | Volume:15 | Issue:2 Page(s): 79-87

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Title

NANOSUSPENSIONS: A NEW APPROACH IN DRUG DELIVERY

Author(s)

AGHAJANI M. | PASHAZADEH A.M. | AMANI A. | MOSTAFAVI S.H. | Issue Writer Certificate

Keywords

NANOSUSPENSION

LOW-SOLUBLE DRUGS

SOLUBILITY

STABILITY

OPTIMIZATION

BIOAVAILABILITY

PARTICLE SIZE DISTRIBUTION

MICROFLUIDIC

NUCLEATION

POLYDISPERSITY INDEX

Abstract

BACKGROUND AND OBJECTIVE: A large number of new development drugs are soluble poorly in both organic and aqueous media which shows a low BIOAVAILABILITY using formulation traditional methods. A promising approach to solve this problem is the formation of NANOSUSPENSIONs. Various articles about the increasing SOLUBILITY and BIOAVAILABILITY of poorly soluble or insoluble drugs by NANOSUSPENSION were evaluated. In formulation of NANOSUSPENSIONs, submicron-sized drug particles are dispersed in a liquid phase then they stabilize using surfactants. With respect to the studies in the subject, in order to eliminate the toxicity or to increase efficiency of drugs, NANOSUSPENSION formulation was used to formulate drug components. The main advantages of this approach are its application for the most drugs and doing it simply. In this work, common approaches of the preparation of NANOSUSPENSIONs, its unique properties, advantages, potential applications and STABILITY evaluation techniques, is mentioned. Considering the specific features of NANOSUSPENSIONs such as, increasing saturation SOLUBILITY and dissolution rate, increased adhesion, ease of manufacturing process and scale-up and versatility (flexibility offered in the modification of surface properties and particle size), there will be many applications for this formulation in different routes of drug delivery.

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APA: Copy

AGHAJANI, M., PASHAZADEH, A.M., AMANI, A., & MOSTAFAVI, S.H.. (2013). NANOSUSPENSIONS: A NEW APPROACH IN DRUG DELIVERY. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 15(2), 79-87. SID. https://sid.ir/paper/608558/en

Vancouver: Copy

AGHAJANI M., PASHAZADEH A.M., AMANI A., MOSTAFAVI S.H.. NANOSUSPENSIONS: A NEW APPROACH IN DRUG DELIVERY. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2013;15(2):79-87. Available from: https://sid.ir/paper/608558/en

IEEE: Copy

M. AGHAJANI, A.M. PASHAZADEH, A. AMANI, and S.H. MOSTAFAVI, “NANOSUSPENSIONS: A NEW APPROACH IN DRUG DELIVERY,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 15, no. 2, pp. 79–87, 2013, [Online]. Available: https://sid.ir/paper/608558/en

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