EFFECTS OF CEFIXIME ON THE TESTIS STRUCTURE AND PITUITARY- GONADAL HORMONES IN ADULT BALB/C MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AHMADI Z.; RAMEZANI M.; SOHRABI D.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Advances in Medical and Biomedical Research Year:2011 | Volume:19 | Issue:74 Page(s): 54-62

Download Full-Text

Persian Verion

View:

8,830

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF CEFIXIME ON THE TESTIS STRUCTURE AND PITUITARY- GONADAL HORMONES IN ADULT BALB/C MICE

Author(s)

AHMADI Z. | RAMEZANI M. | SOHRABI D. | Issue Writer Certificate

Keywords

CEFIXIMEQ3

TESTOSTERONEQ3

GONADOTROPHINSQ2

TESTISQ2

MICEQ2

Abstract

Background and Objective: CEFIXIME is an antimicrobial agent which has a widespread ability against various pathogens, especially gram-negative organisms. Today, physicians apply cephalosporins especially CEFIXIME in a wide scale. Regarding the side effects of some of these antibiotics on reproductive system, this study was conducted to determine the effect of CEFIXIME on pituitary- gonadal hormones, GONADOTROPHINS and testes morphology in adult male MICE.Materials and Methods: Eighteen male MICE (age: 12-16 weeks, weight: 35 5 gr) were divided into three groups; control, sham and experimental (6 MICE in each group). Experimental group received CEFIXIME (0.5 gr/kg/day) as a solution in dimethyl solfoxide (DMSO) for 10 days; the sham group received only drug solvent (DMSO) via IP injection and the control group remained intact. The animals were weighed and sacrificed. Level of hormones was measured by Radioi Immuno Assay (RIA) method. Then, tissues were fixed in Buin's fixative. Sections were cut into 5 µm thicknesses and stained with Hematoxylin and Eosin (H& E). Data were analyzed using T-test and SPSS software.Results: Count of spermatogenic, Sertoli and leydig cells and titer of FSH significantly decreased in the experimental group in comparison with the control and sham groups (P<0.01 and P<0.05). In the experimental group, DHEA hormone decreased significantly (P<0.05) in comparison with sham. No significant differences were seen in other factors between the groups.Conclusion: Regarding physiological role of Sertoli cells during spermatogenesis, reduction of FSH hormone may lead to negative effects on the sperm production and reproductive potential of male MICE.

Cites

No record.

References

No record.

Cite

APA: Copy

AHMADI, Z., RAMEZANI, M., & SOHRABI, D.. (2011). EFFECTS OF CEFIXIME ON THE TESTIS STRUCTURE AND PITUITARY- GONADAL HORMONES IN ADULT BALB/C MICE. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 19(74), 54-62. SID. https://sid.ir/paper/61197/en

Vancouver: Copy

AHMADI Z., RAMEZANI M., SOHRABI D.. EFFECTS OF CEFIXIME ON THE TESTIS STRUCTURE AND PITUITARY- GONADAL HORMONES IN ADULT BALB/C MICE. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2011;19(74):54-62. Available from: https://sid.ir/paper/61197/en

IEEE: Copy

Z. AHMADI, M. RAMEZANI, and D. SOHRABI, “EFFECTS OF CEFIXIME ON THE TESTIS STRUCTURE AND PITUITARY- GONADAL HORMONES IN ADULT BALB/C MICE,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 19, no. 74, pp. 54–62, 2011, [Online]. Available: https://sid.ir/paper/61197/en

Related Journal Papers