CYTOTOXIC EFFECTS OF AQUEOUS AND ALCOHOLIC EXTRACTS OF MENTHA SPICATA LEAVES ON K562 CELL LINE

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ASLANI E.; NAGHSH N.; RANJBAR M.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2015 | Volume:22 | Issue:95 Page(s): 67-79

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Title

CYTOTOXIC EFFECTS OF AQUEOUS AND ALCOHOLIC EXTRACTS OF MENTHA SPICATA LEAVES ON K562 CELL LINE

Author(s)

ASLANI E. | NAGHSH N. | RANJBAR M. | Issue Writer Certificate

Keywords

CYTOTOXICQ2

LEUKEMIAQ2

MENTHA SPICATAQ2

SOXHLET. K562Q2

CMLQ2

Abstract

Background and Objective: Chronic myeloid LEUKEMIA (CML) is a malignant clonal disorder of hematopoietic stem cells which results in increase of myeloid and erythroid cells and platelets in the peripheral blood and hyperplasia in bone marrow. This research evaluated the CYTOTOXIC effect of aqueous, methanolic and ethanolic extracts of M. spicata leaves on K562 cell line as a model of chronic myeloid LEUKEMIA.Materials and Methods: In this experimental trial, leaves of M. spicata were collected from Booin city and extracted using soxhlet method. K562 cells were cultured and treated with concentrations of extracts (12.5-150mg/ml). CYTOTOXICity of M. spicata extracts against K562 LEUKEMIA cells was estimated by the MTT test method. The absorbance was measured using ELISA plate reader at 540 nm.Results: Ethanolic extract showed the highest CYTOTOXIC effect (IC50=75 mg/ml) whereas aqueous extract showed the least CYTOTOXIC effect (IC50=150mg/ml) among the extracts. Methanol extracts showed the CYTOTOXIC effect with IC50=100mg/ml on K562 cell line. Aqueous and alcoholic extracts exhibited a dosedependent CYTOTOXIC effect on K562 cell line.Conclusion: Considering the CYTOTOXIC effects of aqueous and alcoholic extracts of M. spicata leaves on K562 cells, this plant can be considered as a potential candidate for further studies in the treatment of CML.

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APA: Copy

ASLANI, E., NAGHSH, N., & RANJBAR, M.. (2015). CYTOTOXIC EFFECTS OF AQUEOUS AND ALCOHOLIC EXTRACTS OF MENTHA SPICATA LEAVES ON K562 CELL LINE. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 22(95), 67-79. SID. https://sid.ir/paper/61215/en

Vancouver: Copy

ASLANI E., NAGHSH N., RANJBAR M.. CYTOTOXIC EFFECTS OF AQUEOUS AND ALCOHOLIC EXTRACTS OF MENTHA SPICATA LEAVES ON K562 CELL LINE. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2015;22(95):67-79. Available from: https://sid.ir/paper/61215/en

IEEE: Copy

E. ASLANI, N. NAGHSH, and M. RANJBAR, “CYTOTOXIC EFFECTS OF AQUEOUS AND ALCOHOLIC EXTRACTS OF MENTHA SPICATA LEAVES ON K562 CELL LINE,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 22, no. 95, pp. 67–79, 2015, [Online]. Available: https://sid.ir/paper/61215/en

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