THE EFFECT OF PREOPERATIVE ADMINISTRATION OF TRAMADOL ON POST-LAPAROSCOPIC PAIN RELIEF IN WOMEN COMPARED TO PLACEBO

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ATASHKHOUEI S.; JAFARI JAVID M.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2007 | Volume:15 | Issue:59 Page(s): 1-8

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Title

THE EFFECT OF PREOPERATIVE ADMINISTRATION OF TRAMADOL ON POST-LAPAROSCOPIC PAIN RELIEF IN WOMEN COMPARED TO PLACEBO

Author(s)

ATASHKHOUEI S. | JAFARI JAVID M. | Issue Writer Certificate

Keywords

TRAMADOLQ3

PRE-EMPTIVE ANALGESIAQ3

POSTOPERATIVE PAINQ3

SIDE EFFECTSQ3

Abstract

Background and Objective: TRAMADOL is an analgesic with combined opioid agonist and monoamine reuptake blocker properties which may be useful as a preoperative analgesic and antinociceptive adjuvant.The aim of this study was the evaluation of preoperative TRAMADOL administration on pain intensity, postoperative analgesic consumption and SIDE EFFECTS compared to placebo.Materials and Methods: In this randomized, double-blind, placebo-controlled clinical trial 70 infertile, ASA class I or II patients were scheduled for diagnostic gynecologic laparoscopy. Fifty mg TRAMADOL was injected into 35 patients before the operation and the other 35 patients received normal saline. Results: The patients who received preoperative TRAMADOL, had a lower pain score within six hours after the operation (1.31±0.94 compared to 2.93±0.55; p< 0.0001). Ten patients (28.57%) in TRAMADOL group and 33 patients in placebo group had post-operative pain (p< 0.0001). The mean consumption of post-operative TRAMADOL was statistically lower in treatment group (9.46 ±25.92) than in placebo group (45.95 ± 37.96) ;(p<0.0001). Post- operative sedation level 15 minutes (p=0.71) and 30 minutes (p=0.88) after the operation had no significant difference between the two groups. The frequency of post-operative nausea in treatment group (5.71 %) was significantly lower than placebo group (25.71 %); (p=0.04).Conclusion: Administration of a single dose of TRAMADOL one hour before operation provides effective preemptive analgesia in patients undergoing diagnostic gynecologic laparoscopies without affecting sedation level.

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APA: Copy

ATASHKHOUEI, S., & JAFARI JAVID, M.. (2007). THE EFFECT OF PREOPERATIVE ADMINISTRATION OF TRAMADOL ON POST-LAPAROSCOPIC PAIN RELIEF IN WOMEN COMPARED TO PLACEBO. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 15(59), 1-8. SID. https://sid.ir/paper/61417/en

Vancouver: Copy

ATASHKHOUEI S., JAFARI JAVID M.. THE EFFECT OF PREOPERATIVE ADMINISTRATION OF TRAMADOL ON POST-LAPAROSCOPIC PAIN RELIEF IN WOMEN COMPARED TO PLACEBO. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2007;15(59):1-8. Available from: https://sid.ir/paper/61417/en

IEEE: Copy

S. ATASHKHOUEI, and M. JAFARI JAVID, “THE EFFECT OF PREOPERATIVE ADMINISTRATION OF TRAMADOL ON POST-LAPAROSCOPIC PAIN RELIEF IN WOMEN COMPARED TO PLACEBO,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 15, no. 59, pp. 1–8, 2007, [Online]. Available: https://sid.ir/paper/61417/en

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