INTERACTION BETWEEN JWH133-INDUCED ANTINOCICEPTION AND TWO EXTREME DOSES OF CELECOXIB

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GHAHRAMANI Z.; REZAEI KALAJ S.; ZARINDAST M.R.; JAHANGIRI B.; JAFARI M.R.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2009 | Volume:17 | Issue:67 Page(s): 11-21

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Title

INTERACTION BETWEEN JWH133-INDUCED ANTINOCICEPTION AND TWO EXTREME DOSES OF CELECOXIB

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Keywords

JWH133Q3

ANTINOCICEPTIONQ3

CELECOXIBQ3

ULTRA-LOW DOSE (ULD)Q3

MICEQ3

Abstract

Background and Objective: JWH133 is known to have cannabinoid-2 (CB2) receptor agonist properties. CELECOXIB, a selective cyclooxygenase-2 (COX-2) inhibitor, is also known to have antinociceptive properties. Endocannabinoids produce analgesia possibly through cyclooxygenase (COX) pathway. The aim of the present work was: to study the effect of CELECOXIB on JWH133 induced ANTINOCICEPTION and to compare the effects of two different dose ranges of CELECOXIB (mg/kg and nano g/kg) on the JWH133 antiniciceptive effect.Materials and Methods: We have studied the possible interaction of administration of mg/kg (50-200 mg/kg) and Ultra-Low Dose (ULD) (25 and 50 ng/kg) of CELECOXIB on the antinociceptive effect of intraperitoneal (i.p.) injection of JWH133 using formalin test in MICE. Results: JWH133 (0.01, 0.1 and 1 mg/kg) induced antinociceptive effect just in phase I of the formalin test. CELECOXIB (50-200 mg/kg) and its ULD (25 and 50 ng/kg) attenuated and potentiated, JWH133 induced ANTINOCICEPTION, respectively.Conclusions: It is concluded that JWH-133 induced ANTINOCICEPTION is modulated by CELECOXIB and mg/kg doses of CELECOXIB showed opposite effects compare to its ultra-low doses.

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APA: Copy

GHAHRAMANI, Z., REZAEI KALAJ, S., ZARINDAST, M.R., JAHANGIRI, B., & JAFARI, M.R.. (2009). INTERACTION BETWEEN JWH133-INDUCED ANTINOCICEPTION AND TWO EXTREME DOSES OF CELECOXIB. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 17(67), 11-21. SID. https://sid.ir/paper/61491/en

Vancouver: Copy

GHAHRAMANI Z., REZAEI KALAJ S., ZARINDAST M.R., JAHANGIRI B., JAFARI M.R.. INTERACTION BETWEEN JWH133-INDUCED ANTINOCICEPTION AND TWO EXTREME DOSES OF CELECOXIB. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2009;17(67):11-21. Available from: https://sid.ir/paper/61491/en

IEEE: Copy

Z. GHAHRAMANI, S. REZAEI KALAJ, M.R. ZARINDAST, B. JAHANGIRI, and M.R. JAFARI, “INTERACTION BETWEEN JWH133-INDUCED ANTINOCICEPTION AND TWO EXTREME DOSES OF CELECOXIB,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 17, no. 67, pp. 11–21, 2009, [Online]. Available: https://sid.ir/paper/61491/en

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