STUDY OF THE EFFECTS OF HEXAMETHYLENETETRAMINE (HMT) ON THE NUMBER OF PLEURAL VISCERAL LAYER MAST CELLS IN RATS AFTER EXPOSURE TO SULFUR MUSTARD (HD).

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ABDI ZAHRA; SADRAEI S.H.; KAKA GH.R.; JAFARI MAHVASH; SABERI MAHDI; HOSSEINI AKBARI M.H.; DASHTNAVARD H.; PANDOUNEH A.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2009 | Volume:16 | Issue:65 Page(s): 31-40

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Title

STUDY OF THE EFFECTS OF HEXAMETHYLENETETRAMINE (HMT) ON THE NUMBER OF PLEURAL VISCERAL LAYER MAST CELLS IN RATS AFTER EXPOSURE TO SULFUR MUSTARD (HD).

Author(s)

Keywords

SULFUR MUSTARDQ3

LUNGQ3

MAST CELLQ3

HEXAMETHYLENETETRAMINEQ3

RATQ2

Abstract

Background and Objective: SULFUR MUSTARD is a potent chemical vesicant warfare agent that remains a significant military and civilian threat. Inhalation of SULFUR MUSTARD gas causes inflammation and injury to airways and bronchioles. MAST CELLs promote allergic reactions when exposed to some chemical compounds such as HD. HEXAMETHYLENETETRAMINE has been shown to protect human LUNG cells against HD toxicity and has also been shown to be effective against the chemical warfare agent phosgene in vivo. The aim of this study was to evaluate the effects of HMT on the number of MAST CELLs in the lamina propria of visceral layer of pleura in male RATs after exposure to SULFUR MUSTARD.Materials and Methods: Twenty seven Albino Wister male RATs weighting 200±20gr were randomly divided into 5 groups (Normal Saline (N.S), HMT, HD, Pre-exposure and Post-exposure). HD, Pre-exposure and Post-exposure groups received sulfur-mustard and N.S group received Normal Saline as a solvent by intratracheal catheter. HMT, Pre-expand Post-exp groups received HMT via intra-peritoneal for 14 days. After the day 14, body weight changes, the RATe of LUNG tissue injury and the number of MAST CELLs measured in the pleura's visceral layer of the RATs' LUNGs.Results: Histological examination and MAST CELLs count showed no significant difference when compared among NS, HMT, Pre-exposure and Post-exposure groups. However, significant reduction was seen in the number of MAST CELLs in HMT and NS groups in comparison with the HD group (p<0/001). The number of MAST CELLs in the Pre-exposure and Post-exposure groups was also significantly lower than that of the HD group (p<0/001).Conclusions: From the results of this study it can be concluded that HMT may have a positive protective and therapeutic effect on LUNG tissue in RATs.

Cites

STUDY OF THE EFFECTS OF HEXAMETHYLENTETRAMINE ON DECREASE OF DEFECTS OF THE LUNG TISSUE IN THE RAT EXPOSED TO SULFUR MUSTARD

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APA: Copy

ABDI, ZAHRA, SADRAEI, S.H., KAKA, GH.R., JAFARI, MAHVASH, SABERI, MAHDI, HOSSEINI AKBARI, M.H., DASHTNAVARD, H., & PANDOUNEH, A.. (2009). STUDY OF THE EFFECTS OF HEXAMETHYLENETETRAMINE (HMT) ON THE NUMBER OF PLEURAL VISCERAL LAYER MAST CELLS IN RATS AFTER EXPOSURE TO SULFUR MUSTARD (HD).. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 16(65), 31-40. SID. https://sid.ir/paper/61543/en

Vancouver: Copy

ABDI ZAHRA, SADRAEI S.H., KAKA GH.R., JAFARI MAHVASH, SABERI MAHDI, HOSSEINI AKBARI M.H., DASHTNAVARD H., PANDOUNEH A.. STUDY OF THE EFFECTS OF HEXAMETHYLENETETRAMINE (HMT) ON THE NUMBER OF PLEURAL VISCERAL LAYER MAST CELLS IN RATS AFTER EXPOSURE TO SULFUR MUSTARD (HD).. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2009;16(65):31-40. Available from: https://sid.ir/paper/61543/en

IEEE: Copy

ZAHRA ABDI, S.H. SADRAEI, GH.R. KAKA, MAHVASH JAFARI, MAHDI SABERI, M.H. HOSSEINI AKBARI, H. DASHTNAVARD, and A. PANDOUNEH, “STUDY OF THE EFFECTS OF HEXAMETHYLENETETRAMINE (HMT) ON THE NUMBER OF PLEURAL VISCERAL LAYER MAST CELLS IN RATS AFTER EXPOSURE TO SULFUR MUSTARD (HD).,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 16, no. 65, pp. 31–40, 2009, [Online]. Available: https://sid.ir/paper/61543/en

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