INVESTIGATION OF TNF-A CONVERTING ENZYME AND ACTIVITY OF NF-KB IN TOLERANCE TO ISCHEMIA INDUCED BY INTERMITTENT NORMOBARIC HYPEROXIA IN RAT MODEL

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RAHNAMA M.; BIGDELI M.R.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2007 | Volume:15 | Issue:60 Page(s): 63-74

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Title

INVESTIGATION OF TNF-A CONVERTING ENZYME AND ACTIVITY OF NF-KB IN TOLERANCE TO ISCHEMIA INDUCED BY INTERMITTENT NORMOBARIC HYPEROXIA IN RAT MODEL

Author(s)

RAHNAMA M. | BIGDELI M.R. | Issue Writer Certificate

Keywords

NORMOBARIC HYPEROXIAQ3

BRAIN ISCHEMIA TOLERANCEQ3

STROKEQ2

TACEQ3

NF-KB ACTIVITYQ3

Abstract

Background and objective: Recent studies suggest that intermittent and prolonged NORMOBARIC HYPEROXIA (HO) results in ischemic tolerance to reduce brain injury. In this research attempts were made to see the changes in TNF-a converting enzyme (TACE) and NF-KB ACTIVITY following intermittent HO and ischemia preconditioning.Materials and Methods: The rats were divided into two experimental groups, each consisted of 20 animals. The first group was exposed to 95% inspired HO for 4h/day for 6 consecutive days (intermittent HO; InHO). The second group acting as the control was exposed to 21% oxygen in the same chamber (normobaric normoxia or room air; RA) continuously for six days (intermittent RA; InRA). Each main group was subdivided to MCAO-operated (middle cerebral artery occlusion), sham-operated (without MCAO), and intact (without any surgery) subgroups. After 24hr, MCAO-operated subgroups were subjected to 60 min of right MCAO. After 24 h reperfusion, neurologic deficit score (NDS) and infarct volume were assessed in MCAO-operated subgroups. Immediately and 48 h after pretreatment, blood sampling for assessment of serum TNF-a levels were subjected. Then, the effect of intermittent HO and ischemia on NF-KB ACTIVITY and TACE expression were measured.Results: Preconditioning with intermittent HO and ischemia decreased NDS and infarct volume. Moreover InHO and MCAO-InHO upregulate TACE and increase NF-KB ACTIVITY significantly.Conclusion: Although further studies are needed to clarify the mechanisms of ischemic tolerance, InHO and ischemia seem to partly exert their effects via increase upregulation of TACE and NF-KB ACTIVITY.

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APA: Copy

RAHNAMA, M., & BIGDELI, M.R.. (2007). INVESTIGATION OF TNF-A CONVERTING ENZYME AND ACTIVITY OF NF-KB IN TOLERANCE TO ISCHEMIA INDUCED BY INTERMITTENT NORMOBARIC HYPEROXIA IN RAT MODEL. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 15(60), 63-74. SID. https://sid.ir/paper/61592/en

Vancouver: Copy

RAHNAMA M., BIGDELI M.R.. INVESTIGATION OF TNF-A CONVERTING ENZYME AND ACTIVITY OF NF-KB IN TOLERANCE TO ISCHEMIA INDUCED BY INTERMITTENT NORMOBARIC HYPEROXIA IN RAT MODEL. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2007;15(60):63-74. Available from: https://sid.ir/paper/61592/en

IEEE: Copy

M. RAHNAMA, and M.R. BIGDELI, “INVESTIGATION OF TNF-A CONVERTING ENZYME AND ACTIVITY OF NF-KB IN TOLERANCE TO ISCHEMIA INDUCED BY INTERMITTENT NORMOBARIC HYPEROXIA IN RAT MODEL,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 15, no. 60, pp. 63–74, 2007, [Online]. Available: https://sid.ir/paper/61592/en

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