INFLUENCE OF DOPAMINE D1 RECEPTORS OF THE DORSAL HIPPOCAMPUS ON THE HISTAMINE-INDUCED ANXIETY BEHAVIOR IN MICE

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PIRI M.; AYAZI E.; BANANEJ M.; SHAHIN M.S.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2012 | Volume:20 | Issue:79 Page(s): 1-13

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Title

INFLUENCE OF DOPAMINE D1 RECEPTORS OF THE DORSAL HIPPOCAMPUS ON THE HISTAMINE-INDUCED ANXIETY BEHAVIOR IN MICE

Author(s)

PIRI M. | AYAZI E. | BANANEJ M. | SHAHIN M.S. | Issue Writer Certificate

Keywords

SKF 38393Q2

SCH23390Q2

HISTAMINEQ2

ANXIETYQ2

ELEVATED PLUS-MAZEQ2

MOUSEQ2

Abstract

Background and Objective: Dopamine receptors and HISTAMINE influence ANXIETY-like behaviors. Furthermore, interaction between HISTAMINE and dopaminergic D1 receptors has been demonstrated in the modulation of some behavior. In the present study, we investigated the interaction between HISTAMINE and dopaminergic D1 receptors in the dorsal hippocampus in the ANXIETY behavior in mice.Materials and Methods: In this experimental study, the elevated plus maze test was used to test ANXIETY-like behaviors. Mice were anesthetized with intra-peritoneal injection of ketamine hydrochloride, plus xylazine, and two stainless-steel cannuale were placed in the CA1 region of the hippocampus. Two- and one-way analyses of variance (ANOVAs), followed by LSD test, were used for data analysis. All experiments were performed in accordance with the institutional guidelines for animal care and use.Results: Intra-CA1 injection of HISTAMINE and D1 dopamine agonist (SKF 38393) and antagonist (SCH23390) induced ANXIETY. Intra-CA1 injection SKF 38393 or SCH23390 2 min after of effective dose of HISTAMINE (10mg/mouse) inhibited anxiogenic effects of HISTAMINE.Conclusion: It seems that both HISTAMINE and dopaminergic D1 receptors play a role in the modulation of ANXIETY in the dorsal hippocampus of mice, and there is a complex interaction between them.

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APA: Copy

PIRI, M., AYAZI, E., BANANEJ, M., & SHAHIN, M.S.. (2012). INFLUENCE OF DOPAMINE D1 RECEPTORS OF THE DORSAL HIPPOCAMPUS ON THE HISTAMINE-INDUCED ANXIETY BEHAVIOR IN MICE. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 20(79), 1-13. SID. https://sid.ir/paper/61634/en

Vancouver: Copy

PIRI M., AYAZI E., BANANEJ M., SHAHIN M.S.. INFLUENCE OF DOPAMINE D1 RECEPTORS OF THE DORSAL HIPPOCAMPUS ON THE HISTAMINE-INDUCED ANXIETY BEHAVIOR IN MICE. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2012;20(79):1-13. Available from: https://sid.ir/paper/61634/en

IEEE: Copy

M. PIRI, E. AYAZI, M. BANANEJ, and M.S. SHAHIN, “INFLUENCE OF DOPAMINE D1 RECEPTORS OF THE DORSAL HIPPOCAMPUS ON THE HISTAMINE-INDUCED ANXIETY BEHAVIOR IN MICE,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 20, no. 79, pp. 1–13, 2012, [Online]. Available: https://sid.ir/paper/61634/en

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